Author

S. B. Mehta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biophysics· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Approach:microscopy & imaging analysis· 5 Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:imaging· 4 Organism:mouse· 4 Research Focus:clustering· 3

Frequent Co-Authors

I. E. Ivanov· 4 shared J. R. Byrum· 3 shared L.-H. Yeh· 3 shared M. D. Leonetti· 3 shared B. B. Chhun· 2 shared B. Huang· 2 shared C. Liu· 2 shared D. N. Itzhak· 2 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCell Biology

I. E. Ivanov

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Author profile →

9 papers

Recent·Most cited

Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM)

T. Chandler, M. Guo, Y. Su, J. Chen, Y. Wu, J. Liu, A. Agashe, R. S. Fischer, S. B. Mehta, A. Kumar, T. I. Baskin, V. Jamouille, H. Liu, V. Swaminathan, A. Nain, , H. Shroff

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

bioRxiv · Mar 9, 2024 · PreprintBiophysics

Mantis: high-throughput 4D imaging and analysis of the molecular and physical architecture of cells

I. E. Ivanov, E. Hirata-Miyasaki, T. Chandler, R. C. Kovilakam, Z. Liu, S. Pradeep, C. Liu, M. Bhave, S. Khadka, C. Arias, M. D. Leonetti, B. Huang, S. B. Mehta

The paper introduces Mantis, a high-throughput 4D microscope, and shrimPy, software for analyzing 4D data, to study cellular dynamics and responses to perturbations like viral infection.

bioRxiv · Dec 19, 2023Cell Biology

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

M. Y. Hein, D. Peng, V. Todorova, F. McCarthy, K. Kim, C. Liu, L. Savy, C. Januel, R. Baltazar-Nunez, S. Bax, S. Vaid, M. Vangipuram, I. E. Ivanov, J. R. Byrum, S. Pradeep, , M. D. Leonetti

The paper maps subcellular localization of human proteins and shows proteome remodeling during viral infection by combining organelle immuno-capture with mass spectrometry.

bioRxiv · Dec 18, 2023Cell Biology

Correlative imaging of spatio-angular dynamics of molecular assemblies and cells with multimodal instant polarization microscope

I. E. Ivanov, L.-H. Yeh, J. A. Perez-Bermejo, J. R. Byrum, J. Y. S. Kim, M. Leonetti, S. B. Mehta

The paper introduces a new microscope, miPolScope, that enables label-free imaging of molecular and cellular architecture with high speed and resolution, and demonstrates its application on various biological samples.

bioRxiv · Feb 7, 2022Bioengineering

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

N. H. Cho, K. C. Cheveralls, A.-D. Brunner, K. Kim, A. C. Michaelis, P. Raghavan, H. Kobayashi, L. Savy, J. Y. Li, H. Canaj, J. Y. S. Kim, E. M. Setwart, C. Gnann, F. McCarthy, J. P. Cabrera, , M. D. Leonetti

The paper maps human protein localization and interactions using genome engineering, imaging, and data science, revealing functional communities and RNA-binding protein subgroups.

bioRxiv · Mar 29, 2021Cell Biology

POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos

A. Sugizaki, K. Sato, K. Chiba, K. Saito, M. Kawagishi, Y. Tomabechi, S. B. Mehta, H. Ishii, N. Sakai, M. Shirouzu, T. Tani, S. Terada

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

Proceedings of the National Academy of Sciences · Mar 5, 2021Peer-reviewedCell Biology

uPTI: uniaxial permittivity tensor imaging of intrinsic density and anisotropy

L.-H. Yeh, I. E. Ivanov, J. R. Byrum, B. B. Chhun, S.-M. Guo, C. Foltz, E. Hashemi, J. A. Perez-Bermejo, H. Wang, Y. Yu, P. G. Kazansky, B. R. Conklin, M. H. Han, S. B. Mehta

This paper introduces uPTI, a label-free imaging method to measure permittivity tensors in biological samples, enabling 3D orientation and symmetry analysis of cellular structures with high resolution.

bioRxiv · Dec 15, 2020 · PreprintBiophysics

Revealing architectural order with quantitative label-free imaging and deep learning

S.-M. Guo, L.-H. Yeh, J. Folkesson, I. Ivanov, A. P. Krishnan, M. G. Keefe, D. Shin, B. Chhun, N. Cho, M. Leonetti, T. J. Nowakowski, S. B. Mehta

This paper combines label-free imaging with deep learning to analyze biological structures, showing it can predict 3D fluorescent features in tissues.

bioRxiv · Nov 24, 2019Biophysics

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

P. Nordenfelt, T. I. Moore, S. B. Mehta, J. M. Kalappurakkal, V. Swaminathan, N. Koga, T. J. Lambert, D. Baker, J. C. Waters, R. Oldenbourg, T. Tani, S. Mayor, C. M. Waterman, T. A. Springer

The paper shows that integrin orientation is dictated by actin flow direction and cytoskeletal forces during leukocyte migration.

bioRxiv · Aug 27, 2016Cell Biology