Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis
B. J. Y. Tan, K. Sugata, O. Reda, M. Matsuo, K. Uchiyama, P. Miyazato, V. Hahaut, M. Yamagishi, K. Uchimaru, Y. Suzuki, T. Ueno, H. Suzushima, H. Katsuya, M. Tokunaga, Y. Uchiyama, , Y. Satou
This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.
bioRxiv · Sep 1, 2021 · PreprintMicrobiology