M. Matsuo

UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.

Lymphoma cells are circulating in blood of Enzootic Bovine Leukosis and clonality value of virus-infected cells is a useful information for the diagnostic test

The paper demonstrates that clonality values of BLV-infected cells in blood can reliably detect Enzootic Bovine Leukosis and are useful for diagnostic testing.

A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro

The paper develops a new assay to evaluate latency-reversing agents by eliminating HIV-1 proviruses in a long-term cell culture system.

Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis

This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.

Gene expression shapes the patterns of parallel evolution of herbicide resistance in the agricultural weed Monochoria vaginalis

The paper identifies gene expression as a key factor driving parallel evolution of herbicide resistance in Monochoria vaginalis by showing higher expression of specific ALS gene copies.

De novo activated transcription of insertd foreign coding sequences is inheritable in the plant genome

The study shows that de novo transcription of inserted foreign coding sequences in Arabidopsis thaliana is inheritable, with transcriptional activity changing during one generation.

Kozak sequence acts as a negative regulator for de novo transcription initiation of newborn coding sequences in the plant genome

The paper investigates de novo transcription initiation in plant genomes, finding that Kozak sequences repel new TSSs, acting as a selection gate for TSS evolution.

Cryptic promoter activation occurs by at least two different mechanisms in the Arabidopsis genome

The paper identifies two mechanisms of cryptic promoter activation in Arabidopsis: chromatin capture of pre-existing promoter-like regions and de novo promoter formation near inserted LUC ORF sequences.

Plant genome response to incoming coding sequences: stochastic transcriptional activation independent of integration loci

The paper investigates how transgenes acquire transcriptional activity in Arabidopsis thaliana, finding that 30% of promoterless inserts are transcribed independently of integration sites.

Large DNA virus promoted the endosymbiotic evolution to make a photosynthetic eukaryote

This study shows that a large DNA virus played a key role in the rapid genome reorganization and gene transfer during the endosymbiotic evolution of a photosynthetic amoeba.