Q. Xu

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

This study tests a T cell vaccine in HLA-A*02:01 mice to assess its immunogenicity against SARS-CoV-2 variants.

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

This study identifies a conserved SLiM in p107 that mediates B55 recruitment and dephosphorylation, revealing a general mechanism for PP2A/B55 substrate recognition.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

The paper identifies NamZ as an exo-{beta}-N-acetylmuramidase in Bacillus subtilis, showing its role in peptidoglycan degradation and proposing it as a founding member of a new family of hexosaminidases.

This study shows that A-to-I RNA editing in Xanthomonas oryzae enhances iron uptake by modifying the xfeA gene, improving bacterial competitiveness in iron-limited environments.

SingleChannelNet is a deep learning model that automatically classifies sleep stages from raw single-channel EEG data, achieving high accuracy without hand-crafted features or multi-modality data.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

The paper investigates whether pre-existing cutaneous conditions increase SARS-CoV-2 infection risk by examining ACE2 expression and skin barrier function in human and mouse models.

This study develops and evaluates porous scaffolds combining HA, PLGA, and MSM for bone defect reconstruction, showing improved cell adhesion, proliferation, and drug release properties.

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

The paper identifies a novel glymphatic pathway in the optic nerve for clearing amyloid-beta from the vitreous, which is impaired in glaucoma.

This study shows SHIP2 is phosphorylated by EphB2 and contributes to cell repulsion in EphB2-ephrinB1 signaling, but not in reverse signaling.

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

This study models the environmental impact of antibiotic prescribing on antimicrobial resistance in rivers, finding that significant reductions in prescriptions are needed to mitigate resistance gene selection.

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.

This study identifies BmrR as a MarR family regulator that autoregulates the bmrRAB operon in B. longum BBMN68, enhancing bile tolerance through the bile efflux transporter BmrAB.