H. An

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

This study identifies natural antibodies that enable Kupffer cells to capture and kill encapsulated bacteria in the liver, offering a potential therapeutic approach for septic bacterial diseases.

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae during bloodstream infection

The paper identifies that splenic red pulp macrophages, aided by natural antibodies and complement, clear liver-resistant Streptococcus pneumoniae from the bloodstream in mice.

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

The paper designs a selective protein degradation system using bumped IMiD analogs and zinc-finger degrons to target specific proteins without affecting endogenous substrates.

Potent Bacterial Vaccines Require FcγRIIB-mediated Pathogen Capture by Liver Sinusoidal Endothelium

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

A low-power communication scheme for wireless, 1000 channel brain-machine interfaces

This paper evaluates a pulse-interval modulation (PIM) communication scheme for wireless brain-machine interfaces, finding it reduces power consumption while maintaining accurate neural signal transmission.

iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation

This study identifies a new ribosome quality control pathway, iRQC, that responds to ribosome collisions during translation initiation by ubiquitylating and degrading 40S ribosomal proteins.

The Evolutionary History of Wild, Domesticated, and Feral Brassica oleracea (Brassicaceae)

This study clarifies the evolutionary history of Brassica oleracea by identifying B. cretica as its closest wild relative and revealing feral lineages, supporting an Eastern Mediterranean origin.

Brassica rapa domestication: untangling wild and feral forms and convergence of crop morphotypes

This study clarifies the domestication history of Brassica rapa by analyzing genetic diversity and identifying wild and feral forms, suggesting turnips were the first domesticated type.

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress

This study compares the composition of normal stress granules and mutant FUS assemblies in stressed cells, identifying molecular differences and their impact on cellular stress responses in ALS-FUS.

Genes derived from ancient polyploidy have higher genetic diversity and are associated with domestication in Brassica rapa

The paper identifies candidate genes associated with domestication in Brassica rapa and finds that genes from ancient polyploidy are more diverse and linked to domestication.

Phylogeny and Multiple Independent Whole-Genome Duplication Events in the Brassicales

The paper infers phylogenies and places whole-genome duplication events in Brassicales using phylo-transcriptomics and genome survey sequencing.

Rapid and independent evolution of ancestral and novel defenses in a genus of toxic plants (Erysimum, Brassicaceae)

The paper examines the evolution of chemical defenses in Erysimum plants, finding that ancestral and novel defenses evolved independently without trade-offs.

The MarR Family Regulator BmrR is involved in Bile Tolerance of Bifidobacterium longum BBMN68 via Controlling the Expression of an ABC-Transporter

This study identifies BmrR as a MarR family regulator that autoregulates the bmrRAB operon in B. longum BBMN68, enhancing bile tolerance through the bile efflux transporter BmrAB.

Persistent homology demarcates a leaf morphospace

This paper uses persistent homology to analyze leaf shapes from 182,707 leaves across 141 plant families, revealing phylogenetic and geographic differences in leaf morphology.