Author

R. Edmondson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:development & morphogenesis· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

A. Storey· 2 shared A. Tackett· 2 shared G. G. Wang· 2 shared L. Cai· 2 shared S. Byrum· 2 shared S. Mackintosh· 2 shared W. Gong· 2 shared Y.-H. Tsai· 2 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

A. Storey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

H. Zhao, B. K. Das, L. Wang, T. Fujiwara, J. Zhou, N. Aykin-Burns, K. J. Krager, R. Lan, S. G. Mackintosh, R. Edmondson, M. L. Jennings, X. Wang, J. Q. Feng, T. Barrientos, J. Gogoi, , S. Mohan

This study shows that TFR1-mediated iron uptake in osteoclasts affects mitochondrial function and cytoskeleton, leading to increased bone mass in female mice.

bioRxiv · Sep 12, 2021Cell Biology

The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancer

T. Walker, Z. Faraahi, m. price, A. Hawarden, C. Waddell, B. Russell, D. Jones, A. McCormick, N. Gavrielides, S. Tyagi, L. Woodhouse, B. Whalley, C. Roberts, E. Crosbie, R. Edmondson

The paper shows that DDR heterogeneity in ovarian cancer predicts patient outcomes and chemotherapy response by analyzing DDR pathway interactions and constructing predictive DDR signatures.

bioRxiv · Aug 3, 2021 · PreprintCell Biology

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

H. Fan, Y. Guo, Y.-H. Tsai, A. Storey, A. Kim, W. Gong, R. Edmondson, S. Mackintosh, H. Li, S. Byrum, A. Tackett, L. Cai, G. G. Wang

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

bioRxiv · Mar 11, 2021Biochemistry

YY1 cistrome analysis uncovers an essential requirement of the YY1:BRD4-PFKP regulatory axis for promoting tumorigenesis of castration-resistant prostate cancer

L. Cai, C. Xu, Y.-H. Tsai, P. Galbo, W. Gong, A. Storey, Y. Xu, S. Byrum, Y. Whang, J. Parker, S. Mackintosh, R. Edmondson, A. Tackett, J. Huang, D. Zheng, , G. G. Wang

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

bioRxiv · Sep 17, 2020 · PreprintCancer Biology

Copy-number signatures and mutational processes in ovarian carcinoma

G. Macintyre, T. Goranova, D. De Silva, D. Ennis, A. M. Piskorz, M. Eldridge, D. Sie, L.-A. Lewsley, A. Hanif, C. Wilson, S. Dowson, R. M. Glasspool, M. Lockley, E. Brockbank, A. Montes, , J. D. Brenton

This study identifies copy-number signatures in ovarian cancer and links them to mutational processes, showing that most cases involve multiple processes, suggesting therapeutic challenges.

bioRxiv · Sep 4, 2017Cancer Biology