Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages
R. Sato, K. Liu, T. Shibata, K. Hoshino, K. Yamaguchi, T. Miyazaki, R. Hiranuma, R. Fukui, Y. Motoi, Y. Fukuda-Ohta, Y. Zhang, T. Reuter, Y. Ishida, T. Kondo, T. Chiba, , K. MIYAKE
The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.
bioRxiv · May 11, 2023 · PreprintImmunology