S. Mizuno

A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta

This paper introduces a novel genetic mouse model of aortic dissection showing immune cell infiltration and altered ECM dynamics.

Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation

The paper identifies Dusp13 and Dusp27 as MYOD target genes that regulate muscle stem cell transition from proliferation to differentiation during myogenesis.

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

Heart generation via blastocyst complementation in Mesp1/2-deficient mice

This study generates functional adult hearts in Mesp1/2-deficient mice using blastocyst complementation with pluripotent stem cells, showing successful derivation of all cardiovascular lineages from exogenous cells.

Development of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging

This paper develops two mouse strains with Cre-dependent luciferases for in vivo imaging, showing distinct emission spectra and improved brightness for specific tissues.

Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice

This study shows that Prdm13 signaling in the dorsomedial hypothalamus affects age-related sleep-wake changes in mice, and dietary restriction can mitigate these effects.

MTCL2 promotes asymmetric microtubule organizationby crosslinking microtubules on the Golgi membrane

This study identifies MTCL2 as a protein that crosslinks microtubules on the Golgi membrane, promoting asymmetric microtubule organization and supporting directional migration.

MTCL2 promotes asymmetric microtubule organizationby crosslinking microtubules on the Golgi membrane

This study identifies MTCL2 as a protein that crosslinks microtubules on the Golgi membrane, promoting asymmetric microtubule organization and supporting directional migration.

Cables2 Is a novel Smad2-regulatory factor essential for early embryonic development in mice

This study identifies Cables2 as a Smad2-regulatory factor required for early embryonic development in mice, showing its role in gastrulation and gene expression patterns.

ZMYND10 functions in a chaperone relay during axonemal dynein assembly

This study identifies ZMYND10 as a co-chaperone for FKBP8-HSP90 in axonemal dynein assembly, showing its role in ciliary motility and implications for PCD treatment.