Author

R. O'Connell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. H. Welfley· 1 shared A. Martinez· 1 shared A. R. Vap· 1 shared A. Smith· 1 shared B. Bothner· 1 shared B. Haynes· 1 shared B. Scott· 1 shared C. R. Bramham· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBioengineering

A. H. Welfley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Efficient multiple gene knock-out in Colletotrichum higginsianum via CRISPR-Cas9 ribonucleoprotein and URA3- based marker recycling

K. Yonehara, N. Kumakura, T. Motoyama, N. Ishihama, J.-F. Dallery, R. O'Connell, K. Shirasu

The paper develops a CRISPR-Cas9 and URA3-based marker recycling system to efficiently knock out multiple genes in Colletotrichum higginsianum, demonstrating its effectiveness in analyzing virulence factors.

bioRxiv · Apr 20, 2023 · PreprintMicrobiology

Clec12a tempers inflammation while restricting expansion of a colitogenic commensal

J. Round, T. Chiaro, K. Bauer, K. Ost, E. Stephen-Victor, M. Nelson, J. H. Hill, R. Bell, M. Harwood, W. Voth, T. Jackson, K. Klag, R. O'Connell, W. Z. Stephens

This study shows that Clec12a limits inflammation and prevents the expansion of a harmful commensal bacteria, Faecalibaculum rodentium, by enhancing macrophage phagocytosis.

bioRxiv · Mar 16, 2023 · PreprintImmunology

Metabolomic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial Fluid

H. D. Welhaven, A. H. Welfley, P. Pershad, J. Satalich, R. O'Connell, B. Bothner, A. R. Vap, R. K. June

This study identifies distinct metabolomic profiles in synovial fluid associated with knee injury types and patient sex, suggesting metabolic differences linked to post-traumatic osteoarthritis development.

bioRxiv · Feb 3, 2023 · PreprintBioengineering

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

S. Scarneo, A. Smith, J. Favret, R. O'connell, J. Pickeral, K. Yang, G. Ferrari, D. Loiselle, P. Hughes, M. Kulkarni, M. Gargesha, B. Scott, D. Roy, B. Haynes, J. Kweik, T. Haystead

This study identifies eHsp90 as a marker of T cell activation, showing its upregulation in autoimmune diseases and demonstrating the efficacy of an inhibitor in delaying disease progression.

bioRxiv · Jun 6, 2021 · PreprintPharmacology & Toxicology

Molecular determinants of Arc oligomerization and formation of virus-like capsids

M. S. Eriksen, O. Nikolaienko, E. I. Hallin, S. Grodem, H. J. Bustad, M. I. Flydal, R. O'Connell, T. Hosokawa, D. Lascu, S. Akerkar, J. Cuellar, J. J. Chambers, I. Merski, G. Muruganandam, R. Loris, , C. R. Bramham

This paper identifies a 28-amino-acid region in Arc critical for oligomerization and virus-like capsid formation, showing that exogenous RNA enhances assembly.

bioRxiv · Nov 22, 2019 · PreprintBiochemistry