R. O'Connor

An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

Location of CD39+ T cell sub-populations within tumours predict differential outcomes in non-small cell lung cancer.

The paper identifies CD39+ T cell sub-populations in NSCLC tumors and shows their spatial distribution correlates with patient outcomes.

Subpopulations of cancer-associated fibroblasts expressing fibroblast activation protein and podoplanin in non-small cell lung cancer are a predictor of poor clinical outcome

The paper identifies CAF subtypes in NSCLC using flow cytometry and scRNA-seq, showing CAF-S1 and CAF-S5 are associated with poor patient survival.

The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

This study shows cathelicidin promotes Th17 responses and severe EAE by enhancing T cell differentiation and plasticity, and its absence protects mice from disease.

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19

This study compares the antiviral efficacy of PF-00835231, GC-376, and remdesivir in human airway models, showing PF-00835231 is at least as potent as the others and not affected by P-glycoprotein efflux.