J.-H. Liu

Successful spread of mcr-1-bearing IncX4 plasmids is associated with variant in replication protein of IncX4 plasmids

The paper shows that IncX4 plasmids with pir-1 have higher mcr-1 expression and fitness burden but lower invasion rates compared to pir-2 plasmids, explaining why mcr-1 is absent from pir-2 plasmids.

Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4

This study shows GGPP promotes hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4, and inhibiting GGPP synthase reduces these effects.

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

PixR, a novel activator of conjugative transfer of IncX4 resistance plasmids, mitigates the fitness cost of mcr-1 carriage in Escherichia coli

This study identifies PixR as a novel activator of IncX4 plasmid conjugation, showing it reduces the fitness cost of mcr-1 carriage in E. coli.

Quantitative three-dimensional nondestructive imaging of whole anaerobic ammonium-oxidizing bacteria

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.