Author

J. C. Knight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Organism:virus· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. J. Mentzer· 4 shared G. Liu· 3 shared T. Dong· 3 shared X. Yao· 3 shared Y. Peng· 3 shared A. J. Pollard· 2 shared C. Dold· 2 shared D. Dong· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersImmunology

A. J. Mentzer

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

M. Milighetti, Y. Peng, C. C. S. Tan, M. Mark, G. Nageswaran, S. Byrne, T. Ronel, T. Peacock, A. Mayer, A. Chandran, J. Rosenheim, M. Wheelan, X. Yao, G. Liu, S. L. Felce, , B. Chain

The paper identifies high frequency naive T cell precursors that drive rapid T cell responses during early SARS-COV-2 and LCMV infections.

bioRxiv · Nov 8, 2022Immunology

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

T. I. de Silva, G. Liu, B. B. Lindsey, D. Dong, D. Shah, A. J. Mentzer, A. Angyal, R. Brown, M. D. Parker, Z. Yin, X. Yao, L. Turtle, S. Dunachie, COVID-19 Genomics UK (COG-UK) Consortium, M. K. Maini, , T. Dong

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

bioRxiv · Apr 8, 2021Immunology

Investigating the mechanisms of indocyanine green (ICG) cellular uptake in sarcoma

C. D. Chan, M. J. Brookes, R. Tanwani, C. Hope, T. A. Pringle, J. C. Knight, K. S. Rankin

This study investigates ICG uptake mechanisms in sarcoma cells and finds that clathrin-mediated endocytosis is the primary uptake pathway, with proliferation rate correlating with uptake efficiency.

bioRxiv · Apr 5, 2021 · PreprintCancer Biology

Antibody evasion by the Brazilian P.1 strain of SARS-CoV-2

W. - Dejnirattisai, D. - Zhou, P. - Supasa, C. - Liu, A. J. Mentzer, H. M. Ginn, Y. - Zhao, H. M. E. Duyvesteyn, A. Tuekprakhon, R. Nutalai, B. - Wang, G. C. Paesen, C. - Lopez-Camacho, J. - Slon-Campos, T. Walter, , Barne

This study compares antibody resistance of SARS-CoV-2 variants P.1, B.1.351, and B.1.1.7, finding P.1 is less resistant to antibodies despite similar ACE2 binding mutations.

bioRxiv · Mar 12, 2021Microbiology

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

T. Dong, Y. Peng, A. J. Mentzer, G. Liu, X. Yao, Z. Yin, D. Dong, W. Dejnirattisai, L. Turtle, T. Rostron, K. Subramaniam, P. Thomson, P. Zhang, C. Dold, J. Ratcliff, , Lopez-C

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

bioRxiv · Jun 5, 2020Immunology

Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection.

C. Goh, T. Golubchik, M. A. Ansari, M. de Cesare, A. Trebes, I. Elliott, D. Bonsall, P. Piazza, A. Brown, H. Slawinski, N. Martin, S. Defres, M. J. Griffiths, J. E. Bray, M. C. Maiden, , R. Bowden

Castanet, a targeted metagenomic sequencing method, improves pathogen detection in clinical samples by combining sensitivity with cost-effectiveness and broad organism coverage.

bioRxiv · Jul 28, 2019 · PreprintMicrobiology