S. Luo

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

This study identifies TMEM39 as a conserved ER protein that facilitates collagen secretion and prevents ER stress by interacting with COPII components.

This study shows that MB1-47, a mitochondrial uncoupling compound, effectively inhibits T-ALL cell proliferation and extends survival in mouse models without toxicities.

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

This study identifies a naturally occurring ATP5G1 variant in Arctic ground squirrels that enhances mitochondrial function and cell resilience to metabolic stress through a specific amino acid substitution.

This study identifies TMEM-131 family proteins as conserved regulators of collagen assembly and secretion across species, showing their role in ER stress and collagen production.

This study investigates the role of ASK1/p38-mediated NLRP3 inflammasome signaling in diabetic retinopathy, showing its contribution to inflammation and aberrant retinal angiogenesis.

This study shows that Coxiella burnetii phase II can grow under normoxic conditions in ACCM-2 with tryptophan, and its transformant grows robustly without tryptophan, suggesting tryptophan and a temperature-sensitive signal are involved in normoxic growth.

This study examines how cassava/peanut intercropping affects rhizospheric soil physicochemical properties and microbial communities, finding improved nutrient content, pH, and microbial diversity.

This study quantitatively analyzes amino acid sequence variability in HBV proteins to identify conserved and variable regions critical for virus assembly and immune recognition.

This study identifies 208 imprinted genes in rice, showing limited transposable element association, intraspecific variation, and conservation of imprinting at some loci across plant species.