William H. Yong

UC Irvine Brain Initiative Cell Atlas Network (BICAN) Brain Procurement Program for the Center for Multiomic Human Brain Cell Atlas Project

The paper describes a multi-institutional program for collecting neurotypical human brains to support multiomic brain cell atlas studies, highlighting challenges and opportunities for donor recruitment.

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Single-nucleus analysis characterizes non-enhancing region of recurrent high-grade glioma

The paper uses single-nucleus RNA-sequencing to compare non-enhancing and contrast-enhancing regions of high-grade gliomas, finding distinct cellular states and microenvironment features in NE regions.

Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue

The paper creates an Aβ trimer mimic and studies antibodies against it, showing they recognize pathological features in Alzheimer's disease brain tissue.

HIV, Pathology and epigenetic age acceleration in different human tissues

The paper examines epigenetic age acceleration (EAA) across multiple tissues in HIV-infected individuals, finding tissue-specific correlations and associations with clinical conditions and sex.

Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures

This study identifies transcriptomic signatures of human astrocytes across age, sex, and disease states, revealing changes in synaptic function, ionic homeostasis, and tumor microenvironment interactions.