Within- and Between-Family Validation of Nine Polygenic Risk Scores Developed in 1.5 Million Individuals: Implications for IVF, Embryo Selection, and Reduction in Lifetime Disease Risk
Stephan Cordogan, DB Starr, Nathan R. Treff, Jerry S. S. Lanchbury, E Goldstein, K Sadeghi, Margit Burmeister, Lila Dayani, P Macdonald, J. Dianne Keen-Kim, Simon B. Fishel, Enrique Cervantes, Lasse Folkersen
The paper validates nine polygenic risk scores in family and multi-ancestry datasets, showing their potential to reduce disease risk through embryo selection in IVF.
medRxiv · Oct 24, 2025 · PreprintGenetic & Genomic Medicine