Author

Richard J. Paulson

University of Southern California

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

Magdalena Zernicka‐GoetziD· 2 shared Rachel S. MandelbaumiD· 2 shared Aleksandra A. PetelskiiD· 1 shared Alison CampbelliD· 1 shared Ángel MartíniD· 1 shared Antonia WeberlingiD· 1 shared Audrey Qiuyan FuiD· 1 shared Bailey A. T. WeatherbeeiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersDevelopmental Biology

Magdalena Zernicka‐GoetzORCID

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Author profile →

3 papers

Recent·Most cited

A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species

Duo Wang, Hao Ming, Dongshan Yang, Xiang Cui, Zachary Freeman, Li‐Kuang Tsai, Zhuying Wei, Liu Liu, Giovanna Nascimento Scatolin, Brian Bennett, Xiukun Wang, Kimberly Yau, Litao Tao, Xinyi Tong, Shuling Wang, , Qi‐Long Ying

The paper develops a serum-free 6iL/E4 culture system that enables derivation and maintenance of embryonic stem cells (ESCs) across multiple mammalian species, revealing conserved mechanisms for ESC self-renewal.

Cell Research · Jul 13, 2026Peer-reviewedCell Biology

Proteome asymmetry in mouse and human embryos before fate specification

Lisa K. Iwamoto-Stohl, Aleksandra A. Petelski, Baiyi Quan, Maciej Meglicki, Audrey Qiuyan Fu, Shoma Nakagawa, Breanna McMahon, Tingyu Wang, Saad Khan, Harrison Specht, Gray Huffman, Jason Derks, Sergi Junyent, Bailey A. T. Weatherbee, Antonia Weberling, , Magdalena Zernicka‐Goetz

The paper shows proteomic asymmetry in mouse and human embryos that influences lineage segregation.

Cell · Dec 1, 2025Peer-reviewedDevelopmental Biology

Mechanism of cell polarisation and first lineage segregation in the human embryo

Meng Zhu, Marta N. Shahbazi, Ángel Martín, Chuanxin Zhang, Berna Sözen, Máté Borsos, Rachel S. Mandelbaum, Richard J. Paulson, Matteo A. Molè, Marga Esbert, Richard Thomas Scott, Alison Campbell, Simon B. Fishel, Viviana Gradinaru, Han Zhao, , Magdalena Zernicka‐Goetz

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.

bioRxiv · Sep 23, 2020 · PreprintDevelopmental Biology