T. Li

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.

This study uses single-cell RNA sequencing and metabolic profiling to identify metabolic signatures of durable T cell memory in DENV vaccine responses.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

This study identifies BmNPC1 as a critical host receptor for baculovirus infection, showing its interaction with the viral glycoprotein gp64 and role in endosomal fusion.

The paper shows that elevated O-GlcNAcylation in CD4+ T cells enhances Th17 function by altering the lipid microenvironment, increasing IL-17A production in obesity.

This study identifies C. elegans MANF orthologue, shows it binds sulfatide, and demonstrates sulfatide-dependent cytoprotection in both worms and mammalian cells.

This study infects pregnant marmosets with Zika virus, leading to fetal loss and neurodevelopmental issues, mirroring human congenital ZIKV disease.

This study infects marmosets with Zika virus and finds they exhibit key features of human disease, including asymptomatic infection and viral persistence in lymph nodes.

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.

This study identifies and characterizes NF-Y transcription factors involved in rice endosperm development, showing sub-functionalization and interaction patterns among subunits.

This study identifies 208 imprinted genes in rice, showing limited transposable element association, intraspecific variation, and conservation of imprinting at some loci across plant species.

This study tracks the molecular evolution of a pediatric ependymoma through multiple treatments, revealing how therapy shapes tumor subclonal diversity and neo-antigen landscapes.

The paper evaluates the PURE system for in vitro protein synthesis, identifying factors affecting protein yield and activity, and proposes optimizations to improve performance.