W. Wang

This study evaluates the efficacy of a ketogenic diet in preclinical models of IDH wild-type and IDH mutant gliomas, finding no significant effect on tumor growth or survival.

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

This study simulates reentrant arrhythmias in ischemic hearts with multiple electrophysiological remodelling stages, showing that spatial heterogeneity of refractory periods and excitation threshold differences drive reentry depending on border orientation relative to wavefronts.

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This study examines how resetting affects the ergodicity and mean-squared displacements in fractional Brownian motion and heterogeneous diffusion processes, revealing nonergodicity and nonmonotonicity in the ergodicity breaking parameter.

This paper introduces RPnet, a neural network method for coarse-graining metastable conformational states in protein dynamics, showing comparable or better results than existing methods.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

The paper identifies RYR1 as a key channel regulating sweet and umami perception in rats through Ca2+ dynamics and proposes a metabolic clock model.

The paper calculates folding thermodynamics of WW domain variants using simulations and predicts effects of guanidine hydrochloride concentration changes.

The paper evaluates resistance of 25 therapeutic antibodies to SARS-CoV-2 variants with multiple spike substitutions, finding key substitutions predict resistance but other substitutions can modify it unpredictably.

This study investigates how retrocyclin-101 inhibits flavivirus infection by targeting the NS2B-NS3 protease and the DE loop of the E glycoprotein.

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

The paper investigates how inertia affects the ergodic properties of fractional Brownian motion, showing that it changes the ergodicity breaking parameter and the equivalence between ensemble- and time-averaged MSDs.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

This study examines the distribution of transcriptional outputs in Myc-amplified medulloblastoma cells and identifies IMPDHs as a therapeutic target.

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

This study identifies Reg4 as an antimicrobial peptide that combats Salmonella Typhimurium by binding flagellin and inhibiting bacterial motility, adhesion, and invasion.

This paper introduces LCTC, a method to quantify structural distributions in heterogeneous cryo-EM datasets, showing improved performance over existing methods on simulated and experimental data.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

The paper characterizes the subunit composition and structure of native adult glycine receptors, showing a 4:1 stoichiometry of 2 and β subunits and their functional implications.

The paper identifies cold resistance in a nematode population and finds genetic and transcriptional differences between temperate and tropical strains.

This study evaluates variant calling tools for detecting minority variants in viral sequencing data and provides guidance for accurate quantification of intrahost viral diversity.

This study identifies four residues in Lassa virus GP1 critical for receptor switch to LAMP1, showing their impact on binding affinity and infectivity.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study identifies PcDHCR7 in Phytophthora capsici as a {bigtriangleup}7-sterol reductase essential for mycelium development and pathogenicity.