W. Wang

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

The paper presents a method to identify Markov model topologies for ion channel dynamics using experimental data from two types of voltage-gated ion channels.

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

This paper demonstrates that non-T-cell based antigen depletion can induce apoptosis in CD19-expressing cancer cells, proposing a universal cellular therapy strategy using artificial antigen-recognizing cells.

This paper shows that lipoylated H-protein can catalyze glycine cleavage and synthesis reactions in vitro without the other GCS proteins.

DrugComb updates its repository and analysis tools to include more comprehensive drug combination and monotherapy data, enhanced algorithms, network modeling, and machine learning models for predicting drug sensitivity and synergy.

The paper develops an electrochemical immunosensor for detecting azocyclotin residues using Co3O4/PAn nanoparticles, achieving good sensitivity and accuracy in agricultural samples.

This study identifies biomarkers and candidate regulators in multiple myeloma under AURKA knockout using bioinformatics analysis of gene expression data.

This study shows that combining DNMT and NAMPT inhibitors with platinum reduces OCSCs and tumorigenesis in ovarian cancer.

The paper identifies a noncanonical mRNA decay process, RIDDLE, mediated by IRE1α oligomers in cancer cells, which promotes survival by degrading mRNAs without XBP1-like endomotifs.

This study uses rational protein engineering to enhance cold activity in a thermophilic lipase without compromising thermostability.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study evaluates how N-linked glycans on Lassa virus GPC affect immune response, finding that glycan deletion enhances effector T cell proportions and antibody titers, suggesting potential for vaccine design.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

This study shows that sucrose synthase is not required for cellulose biosynthesis in Arabidopsis, as mutants lacking all six SUS genes show no growth defects or changes in cellulose content.

This study compares the antitumor effects of live and heat-inactivated oncolytic vaccinia viruses and identifies immune mechanisms underlying their efficacy.

The paper identifies accelerated evolution in the Nrk gene's exons in eutherian mammals, suggesting a new exon ignited positive selection linked to placental development.

The paper uses single-cell ATAC and RNA sequencing to identify pre-existing and treatment-persistent stem-like cell subpopulations in prostate cancer models that predict treatment response.

This paper reports a unique enzyme, LplA, that forms a stimuli-responsive and reversible hydrogel with catalytic activity, revealing its structural and functional mechanisms.

The paper presents the cryo-EM structure of the human Nav1.5-E1784K variant and identifies a mutational hotspot in fast inactivation segments linked to LQT3.

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.

The paper tests the synergistic anti-cancer effects of pyrazolopyrimidinones combined with cold atmospheric plasma against glioblastoma cells and identifies two prodrugs that show enhanced cytotoxicity in combination.

The paper compares starch granule sizes in maize parental lines and hybrids, finding a maternal inheritance trend in seed starch granule size.

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.

This study identifies PDGFRβ as a host factor required for JEV infection and shows that imatinib can protect against JEV by reducing viral load and histopathology.

The paper resolves a 20-year controversy by showing that ADPG pyrophosphorylase in chloroplasts, not sucrose synthase in the cytosol, is the primary source of ADPG for starch synthesis in Arabidopsis leaves.

This study isolates and characterizes testicular extracellular vesicles, identifies their cargo, and shows their role in inter-compartmental communication during spermatogenesis.