W. Wang

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

This study describes an Early Triassic sauropterygian skeleton, identifies its phylogenetic position, and highlights the ancestral body plan and adaptive radiation of marine reptiles.

This study shows cystin deficiency reduces fibrocystin (FPC) levels in mouse renal cells, leading to proteome changes and cyst formation similar to ARPKD.

DecentTree improves Neighbour-Joining phylogenetic inference scalability, handling large datasets up to 64,000 SARS-CoV-2 genomes faster than existing methods.

This study shows that an Omicron-matched DNA vaccine booster enhances cross-reactive immunity against Delta and Omicron variants in mice compared to an ancestral strain booster.

The paper was withdrawn due to the authors performing additional experiments to further test their conclusions.

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

The paper uses photo-crosslinking and computational docking to determine the in situ cell-surface conformation of the TCR-CD3 complex, revealing a novel arrangement of CD3 subunits around the TCR.

This study shows platinum treatment increases mitochondrial activity and OXPHOS in ovarian cancer cells, leading to enrichment of cancer stem cells, which can be blocked by OXPHOS inhibitors.

The paper identifies keystone species in synthetic microbial biofilm communities that influence their productivity through metabolic facilitation or competition.

This study reveals that water-bridged interactions facilitate Ca2+ binding and allostery in calmodulin by reducing energy landscape ruggedness and enabling asymmetric EF-hand responses.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

This study evaluates the functional effects of 21 common sweeteners on human gut microbiomes using metaproteomics, identifying potential prebiotic properties in certain sugar alcohols.

A third dose of Pfizer/BioNTech vaccine significantly boosts Omicron neutralizing antibodies, while convalescent sera and therapeutic antibodies show variable and often low neutralization.

The paper identifies recurrent cancer cell states across 15 tumor types and examines their interactions with the tumor microenvironment using single-cell RNA-Seq and spatial transcriptomics.

This study shows that accumulated Treg cells in aged mice worsen experimental autoimmune encephalomyelitis (EAE) by disrupting Treg/Teff balance and impairing CNS immune cell trafficking.

The paper investigates the origin of the SARS-CoV-2 Omicron variant, finding evidence suggesting it jumped from humans to mice and then back to humans.

This study shows DRP1 clusters at mitochondria-SR contact sites via β-actin, maintaining mitochondrial quality control in adult hearts despite reduced DRP1 levels.

This paper introduces a method using nanomechanical resonators to measure AAV vector mass with high precision, enabling real-time quality control in biomanufacturing.

This study evaluates the neutralization resistance and spike protein properties of SARS-CoV-2 B.1.617 variants, finding modest resistance to sera and therapeutic antibodies, but enhanced cleavage and fusogenic activity in Delta variants.

This study shows weakly migratory breast cancer cells use microvesicle-Tg2 to activate fibroblasts, promoting metastasis through tumor stiffening and fibroblast activation.

This study determines the cryo-EM structure of VAR2CSA and its complex with CSA, revealing conformational changes and identifying mutations that abolish CSA binding and cytoadherence to placental and tumor cells.

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

This study shows YY1 forms phase-separated super-enhancers by compartmentalizing coactivators and enhancer elements, with a histidine cluster essential for this process.

This paper uses a data-driven fish school model to study how perceptual and cognitive factors affect collective swimming patterns in Hemigrammus rhodostomus, finding that minimal alignment and attraction are required for schooling, and that stronger interactions or larger group sizes can disrupt coordination.