W. Zhang

This paper determines the structure of tau filaments from Pick’s disease using cryo-EM, revealing a novel tau protein fold distinct from Alzheimer's disease filaments.

This study uses time-resolved crystallography to directly observe nonenzymatic RNA primer extension, revealing key intermediates and their structural organization.

This study identifies mutations in specific genes associated with clofazimine resistance in Mycobacterium abscessus through whole genome sequencing of resistant mutants.

The paper shows that Shine-Dalgarno sequence accessibility affects N-terminal codon bias in E. coli by modulating translation initiation efficiency.

This study identifies novel germline V and J alleles in Rhesus macaques by analyzing BCR repertoires and validates them using whole genome sequencing and alignment reference.

This study shows SlARF10 regulates chlorophyll and sugar accumulation in tomato fruits by controlling starch synthesis and photosynthesis.

The paper identifies novel mutations in several genes associated with pyrazinoic acid/pyrazinamide resistance in Mycobacterium tuberculosis.

The paper shows that DARPP-32 and t-DARPP promote lung cancer growth via IKKα-dependent migration and Akt/Erk-mediated survival, with t-DARPP linked to poor survival and higher tumor stages.

This study shows that aging of antiviral CD8+ memory T cells leads to increased survival, metabolic adaptations, and lymphoid tissue homing, enhancing their recall response capabilities.

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.

This study compares glucose administration methods in Japanese flounder, showing different insulin and brain-gut peptide responses, and suggests a negative feedback mechanism in glucose homeostasis.

The paper introduces a new method to estimate soil organic carbon stocks by accounting for soil volume changes, revealing an additional carbon sink in global forests.

This study identifies a novel family of polyketides in Clostridium acetobutylicum that regulate butanol production and differentiation processes.

The paper identifies a conserved gene cluster in Actinobacteria that synthesizes isonitrile lipopeptides (INLPs) via a unique thio-template mechanism and links it to metal transport in Mycobacterium marinum.

This study identifies AST1, a Trihelix transcription factor in Arabidopsis, which enhances abiotic stress tolerance by binding to AGAG-box and GT motifs, regulating stress-related genes and physiological traits.

The paper shows that a synthetic sulfated RaxX peptide mimics plant PSY peptides to promote root growth and that XA21 recognizes microbial RaxX to trigger immunity.

This study identifies 17 novel genes associated with D-cycloserine resistance in Mycobacterium tuberculosis through whole genome sequencing of resistant mutants.

The paper investigates how common tuberculosis drugs affect clofazimine activity in vitro and explores its potential for treating multi-drug-resistant TB.

This study identifies drugs that enhance pyrazinamide's anti-persister activity by screening a clinical drug library against M. tuberculosis cultures enriched with persisters.