X. Zeng

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

This study evaluates a SARS-CoV-2 spike ferritin nanoparticle vaccine's effectiveness against B.1.1.7 and B.1.351 variants in hamsters, showing protection against disease and viral replication.

This study investigates how L-alanine, an amino acid-derived quorum sensing molecule, enhances the gastrointestinal tolerance of Lactobacillus acidophilus in a co-culture fermentation model.

The paper shows that liver generates NADPH for lipogenesis through serine catabolism, distinct from adipose which uses glucose and the pentose phosphate pathway.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

This study compares aerosol and intranasal SARS-CoV-2 exposure in macaques, finding aerosol exposure in cynomolgus macaques causes more severe disease than other models.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

This study evaluates an adjuvanted SARS-CoV-2 RBD nanoparticle vaccine in macaques, showing robust immune responses and protection against viral challenge and variants.

This study infects rhesus macaques intravaginally with Zika virus and finds that two of three pregnancies resulted in early embryonic loss with viral RNA detected at the maternal-fetal interface.

A SARS-CoV-2 Spike ferritin nanoparticle vaccine induces broad neutralizing antibodies and protects nonhuman primates against respiratory infection and disease.

The paper estimates hydration free energies of model compounds mimicking charged amino acid sidechains using TCPD and AMOEBA simulations, revealing structural and thermodynamic differences between acidic and basic residues.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

This study investigates EEEV pathogenesis in cynomolgus macaques following aerosol challenge, finding that the virus replicates in the olfactory bulb and spreads via axonal transport, causing neuronal dysfunction rather than death.

This paper designs intrinsically disordered proteins with LCST phase behavior using Monte Carlo simulations and genetic algorithms.

This study evaluates a SARS-CoV-2 DNA vaccine in Syrian hamsters, showing it is protective in both healthy and immunosuppressed models.

This study shows that using a jet injection device improves the immunogenicity of hantavirus DNA vaccines in hamsters compared to traditional methods.

This study identifies HetF as a new divisome component in Anabaena PCC 7120, showing its role in cell division and its interaction with FtsI.

This study identifies IL-22's role in renal metabolic reprogramming through PFKFB3 to treat kidney injury in animal models.

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

This study infects nonhuman primates with SARS-CoV-2 via airborne exposure and compares disease progression across species.

This study shows that disrupting adaptive immunity in Syrian hamsters worsens SARS-CoV-2 disease, but a neutralizing antibody reduces infection even in immunosuppressed animals.

This study reports the crystal structure of a far-red-sensing cyanobacteriochrome and identifies key protein-chromophore interactions that enable far-red light perception.

This study shows that seminal plasma exosomes increase human sperm calcium levels via the CatSper channel, improving motility and offering potential clinical applications for asthenozoospermia.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study identifies three Npl4 conformational states in the human p97 complex using cryo-EM and shows how a disulfiram derivative inhibits p97 by disrupting Npl4 zinc finger interactions.

The paper introduces a computational approach to predict sequence-specific phase diagrams for intrinsically disordered proteins by combining simulations with Gaussian cluster theory.

The paper identifies and evaluates reagents and assays for detecting SARS-CoV-2 in FFPE specimens using IHC, IFA, RNAscope, and mFISH techniques.

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

This study shows that Nrf2 represses ER stress-related ferroptosis in renal carcinoma cells through the HO-1 pathway, suggesting it as a potential therapeutic target.

This study shows GLUL promotes lung cancer cell growth under glutamine sufficiency through enzyme-independent upregulation of CaMK2G.