Author

Xiarong Shi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:DNA methylation· 1 Organism:non-human primate· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Connor McGinnis· 3 shared Dane Z. HazelbakeriD· 3 shared Daniel J. O’ConnelliD· 3 shared Jonathan D. FinniD· 3 shared Sandeep KumariD· 3 shared Anne M. Bara· 2 shared Brett EstesiD· 2 shared Chong T. LuoiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Connor McGinnis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Highly Efficient Multiplexed Genome Engineering and Clone Selection to Enable Next Generation Induced Pluripotent Stem Cell (iPSC)-based Cell Therapies

Kaivalya Molugu, Ruba Halaoui, Mohammed Zeaiter, Anne M. Bara, Matthew H. Bakalar, Bruna Castro de Oliveira, Connor McGinnis, Jie Wang, Marie-Joe Kimaz, Lauren Herchenroder, Arun Bhattathiri, Alexander Allen, Minggang Fang, Davood Norouzi, Didac Santesmasses, , Chong T. Luo

This paper introduces a novel genome engineering method for iPSCs that enables efficient multiplex gene editing and clone selection, improving the precision and speed of iPSC-based therapies.

bioRxiv · Dec 25, 2025 · PreprintGenomics

Curative levels of endogenous gene replacement achieved in non-human primate liver using programmable genomic integration

Jenny Xie, Maike Thamsen Dunyak, Patrick Hanna, Angela Xinyi Nan, Brett Estes, Jesse C. Cochrane, Shuai Wu, Jie Wang, Connor McGinnis, Qiang Wang, Rejina Pokharel, Dev Paudel, Jason Zhang, Dan Li, Parth H. Amin, , Jonathan D. Finn

This paper demonstrates programmable genomic integration in non-human primate liver, achieving curative levels of gene expression in over 50% of liver cells.

bioRxiv · Oct 12, 2024 · PreprintBioengineering

Large Serine Integrase Off-target Discovery and Validation for Therapeutic Genome Editing

Dane Z. Hazelbaker, Japan B. Mehta, Connor McGinnis, Didac Santesmasses, Anne M. Bara, Xiaoyu Liang, Thomas C. Biondi, Tim J. Fennell, Nils Homer, Brett Estes, Jenny Xie, Davood Norouzi, Kaivalya Molugu, Ravindra Amunugama, Chong T. Luo, , Daniel J. O’Connell

The paper develops and validates methods to detect off-target recombination by Large Serine Integrases, finding higher sensitivity than whole genome sequencing.

bioRxiv · Aug 23, 2024 · PreprintGenomics