Y. Feng

The paper identifies a canine mammary tumor subtype that molecularly resembles human basal-like breast cancer, suggesting it as a potential translational model.

This study identifies BRD9 as a key regulator of pancreatic cancer stem cell stemness and tumorigenesis, showing that its inhibition reduces CSC self-renewal and enhances chemotherapy response.

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

The paper identifies age-related protein structural changes in yeast and shows that inhibiting polymerization of glutamate synthase extends lifespan.

This study identifies potent pan-sarbecovirus neutralizing antibodies from vaccinated macaques, showing broad neutralization against SARS-CoV-2 variants and related viruses.

This paper reports the crystal and cryo-EM structures of GlnR-DNA and GlnR-TAC complexes, revealing the transcription activation mechanism of GlnR in actinobacteria.

This study shows that preneoplastic cells exhibit Warburg metabolism early on, which can be targeted to eliminate them using metabolic inhibitors.

This study shows that hematopoietic Dnmt3a haploinsufficiency worsens colitis-associated colon cancer by promoting angiogenesis, which can be targeted with axitinib.

This study fills mitogenomic gaps in leptosporangiate ferns and identifies 71 evolutionary regime shifts across 218 land plant species, revealing patterns of genomic convergence and divergence.

The study analyzes viral diversity in individual bats to assess co-infection, spillover, and zoonotic risk of potential viruses.

This study predicts nasal spray vaccine droplet behavior and immune response in a 6-year-old's nasal cavity to improve COVID-19 prevention.

The paper reports cryo-EM structures of cyanobacterial transcription initiation complexes and identifies an SI3-{sigma} arch that stabilizes the RNAP-promoter DNA open complex, essential for transcription initiation.

This study identifies NR2F6 as a melanoma-intrinsic regulator of anti-tumor immunity, showing that its inhibition enhances immunotherapy response and tumor suppression.

The paper describes a high-throughput method to screen V-ATPase inhibitors/activators using Acridine Orange in yeast vacuoles.

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

This paper develops a lab-on-a-chip method for analyzing biomolecular processes with high sensitivity and single molecule resolution in physiological conditions.

This study investigates how mental health interventions affect Alzheimer's disease progression through immune mechanisms in transgenic mice.

The paper uses long-term experimental data to test hypotheses about plant diversity loss under nutrient enrichment, finding support for competitive asymmetry and soil acidification over niche dimension.

This study maps lactylation sites in Toxoplasma gondii and identifies its role in gene regulation and metabolic processes.

This study compares genome rearrangement features across ciliates to understand the evolutionary origin of massively scrambled genomes.

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This paper identifies CRISPR-Cas immunity in Trichodesmium thiebautii as a factor contributing to its numerical dominance over T. erythraeum in oceanic nitrogen fixation.

This study shows bumblebees use only ordinal memory of foraging options, not absolute reward values, when making decisions in novel pairings.

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

This paper introduces a method to create autonomously regulated oxygen microenvironments in microscale cell cultures using an oil overlay, validated with simulations and experiments across multiple cell types.

This study examines the bladder microbiome, metabolome, and cytokines in SLE patients, finding associations between microbial composition and disease-related metabolites and cytokines.