Y. Feng

This study shows Hantaan virus uses mitochondrial OXPHOS for replication, driven by AKT activation and PNPT phosphorylation.

This study identifies Siah1/2 as E3 ligases that degrade dissociated CycT1 in resting cells, preventing P-TEFb formation.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This study identifies melanoma addiction to GCDH, showing that GCDH controls NRF2 glutarylation, which limits apoptotic UPR signaling and tumor growth.

This study identifies shared hotspot mutations in canine and human cancers, highlighting dogs as a valuable model for precision cancer therapeutics.

The paper models aerosol particle transport through lung mucus using computational fluid dynamics to predict penetration and distribution, considering mucus properties and particle interactions.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

This paper resolves conflicts in the evolutionary placement of Nanohaloarchaea and Methanonatronarchaeia using phylogenetic and phylogenomic data, showing Nanohaloarchaea share a sister relationship with Haloarchaea.

This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.

This paper introduces BATTLES, a high-throughput method that applies biomechanical force to screen pMHCs for T-cell activation, revealing force- and sequence-dependent responses.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

The paper develops a new assembly strategy to improve mitogenome reconstruction in plants, revealing mosaic structures and horizontal transfer contributions to mitochondrial evolution.

This study shows that gut microbiota in Anopheles stephensi affects tryptophan metabolism, with Pseudomonas alcaligenes reducing 3-HK to protect against Plasmodium infection.

The paper identifies paralogue-specific protein interactions of the MGCC module in the NuRD complex, revealing mechanisms for functional specificity and integration into other complexes.

This study identifies FAM72A as a regulator of mutagenic uracil repair during antibody maturation by antagonizing UNG2 activity.

The paper shows DNA demethylation of Foxp3 enhancer CNS2 switches transcriptional drivers to maintain Treg identity by stabilizing Foxp3 expression.

This study identifies INS1 as a protease critical for macrogamont formation and oocyst production in Cryptosporidium parvum, with loss of INS1 reducing virulence in mice.

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

The paper introduces Deep-LUMEN, a deep learning algorithm for classifying lung epithelial spheroids from brightfield images, and validates its ability to detect morphological changes in response to drug treatments.

This paper proposes a gait-symmetry-based human-in-the-loop optimization method for unilateral transtibial amputees, improving gait symmetry and reducing metabolic cost.

This study develops TTA-UC-PLGA nanoparticles for in vivo cancer imaging and drug delivery, showing sustained UC signal detection in tumors 96 hours post-administration.

This study shows that eurycomanone promotes lipolysis and reduces fat accumulation by activating the cAMP/PKA pathway in 3T3-L1 cells and C57BL/6J mice.

This study evaluates three fecal immunoassay technologies for detecting canine Echinococcus infection in China, finding that sensitivity is lower than expected and further development is needed.

The paper analyzes canine cancer mutation rates across breeds and cancer types, finding a positive correlation with TP53 mutations and a breed-specific mutation signature in Golden Retrievers.

The paper introduces MRBLEs 2.0, a method for high-throughput synthesis of functionalized microspheres with spectral and magnetic encoding, demonstrating efficient conjugation of biomolecules and magnetic nanoparticle incorporation.