Y. He

This study uses HDX-MS to identify structural determinants of RORγ hyperactivation by synthetic agonists, showing correlations between receptor dynamics and activity.

This study investigates the dynamic metabolic changes in Ulva prolifera during fragmentation-induced proliferation, identifying key metabolites involved in reproduction and stress response.

This study identifies prohibitin as a urine biomarker for Wilms tumor relapse and shows it promotes chemotherapy resistance by disrupting mitochondrial apoptosis.

This study shows that inhibiting EZH2 reduces lupus-like disease in MRL/lpr mice by improving survival and decreasing anti-dsDNA antibodies and inflammation.

This paper evaluates tree shape distance metrics to quantify cophylogeny in host-pathogen interactions and identifies metrics that best capture coevolutionary parameters.

The paper introduces domain insertion permissibility as a metric to identify engineerable allosteric sites in ion channels, showing light sensitivity when inserted into allosteric sites.

This study uses computational modeling to analyze how odor-capture structures in Pancrustacea function in water and air, finding key differences in sensitivity to parameters like Reynolds number and gap width.

This study shows autophagy promotes osimertinib resistance in EGFR-mutant lung cancer by enhancing stem-cell like properties, and inhibiting autophagy reverses resistance.

The paper shows MTAP loss in GBM correlates with an immunosuppressive profile by increasing M2 macrophages and that MTA, a byproduct of MTAP loss, promotes this effect through the A2B receptor.

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.

This study investigates the role of the apical polar ring in Toxoplasma gondii by analyzing KinesinA and APR1, showing its structural importance for microtubule organization and parasite function.

This study demonstrates that Cpf1 nucleases from Francisella novicida and Lachnospiraceae bacterium ND2006 can efficiently insert genes into the rice genome via homology directed repair.