Y. He

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

This study identifies SARS-CoV-2's high fusogenic activity via ACE2 receptor and designs a potent lipopeptide inhibitor, IPB02, targeting the HR2 region of the spike protein.

This paper develops 3D printing inks that resist bacterial biofilm formation and demonstrate their use in a finger prosthetic to prevent infection.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

This study identifies positive selection in the SARS-CoV-2 spike gene, particularly the D614G mutation, which may enhance viral entry and adaptability during the pandemic.

The paper develops an IP-MS assay to identify slow-growing mycobacterial species in early MGIT cultures using species-specific antibodies.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

This study shows that combining chidamide and doxorubicin synergistically inhibits anaplastic thyroid carcinoma by inducing autophagy via the PI3K/Akt/mTOR pathway.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

This study reports cryo-EM structures of a P4-ATPase lipid flippase in lipid bilayers, revealing mechanisms of lipid transport and ATP coupling.

This study identifies B- and T-cell epitopes from SARS-CoV-2 surface glycoprotein using immune-informatics approaches, confirming their antigenicity and compatibility with HLA alleles for potential vaccine development.

The paper quantifies species-specific CpG distribution patterns across genomic scales and shows their correlation with chromatin structure in mammals and avians.

The paper uses single-cell RNA sequencing to identify new markers and functions of lymphatic endothelial cell subpopulations in murine lymph nodes.

This study identifies GmPTF1 as a regulator of GmEXPB2 expression, modifying soybean root architecture to enhance phosphate acquisition and biomass.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

This study identifies a non-genetic mechanism for cisplatin resistance in lung adenocarcinoma involving the integrin β4/paxillin axis and its regulation of USP1 and VDAC1.

The paper assesses CRC screening and follow-up colonoscopy rates in a Chinese urban district, finding low participation and follow-up rates despite high CRC prevalence.

This study shows overexpressing CsGH3.1 and CsGH3.1L in citrus reduces susceptibility to Xcc by repressing auxin signaling and enhancing defense responses.

The paper uses gold nanorods to track fluid dynamics above swarming bacteria, revealing superdiffusive transport flows that enable long-range material transport and population-level communication.

This paper develops a syngeneic mouse model of tobacco-associated HNSCC that shows high response rates to anti-CTLA-4 therapy.

This study quantifies selective pressures on human pigmentation genes across populations and time periods, finding directional selection on light and dark pigmentation traits.

This study uses STED nanoscopy with a new dye to visualize mitochondrial cristae dynamics in live cells at high resolution.

The paper introduces a presuppositionless method to analyze single nanoparticle trajectories by leveraging their historical data, revealing spatiotemporal patterns without predefined models.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

This study shows that mitochondrial dynamics and mitophagy are essential for the invasive growth of Magnaporthe oryzae during rice blast disease.