Author

Y. Kanai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Jin· 2 shared O. Nureki· 2 shared R. Ohgaki· 2 shared Y. Lee· 2 shared A. R. Piacenti· 1 shared C. Gabutt· 1 shared G. Murshudov· 1 shared H. Endou· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

C. Jin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis of anticancer drug recognition and amino acid transport by LAT1

Y. Lee, C. Jin, R. Ohgaki, M. Xu, S. Ogasawara, R. Warshamanage, K. Yamashita, G. Murshudov, O. Nureki, T. Murata, Y. Kanai

This study reports six LAT1 structures bound with ligands, revealing substrate recognition and inhibition mechanisms, including the role of JPH203 as an anticancer drug.

bioRxiv · Dec 3, 2023Biochemistry

Lab-on-a-graphene-FET detection of key molecular events underpinning influenza virus infection and effect of antiviral drugs

T. Ono, K. Kamada, R. Hayashi, A. R. Piacenti, C. Gabutt, N. Sriwilaijaroen, H. Hiramatsu, Y. Kanai, K. Inoue, S.-i. Nakakita, T. Kawahara, Y. Ie, Y. Watanabe, Y. Suzuki, S. Contera, K. Matsumoto

This study uses graphene-FETs to detect molecular events during influenza infection and monitor antiviral drug effects in real-time.

bioRxiv · Mar 18, 2020 · PreprintBioengineering

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Y. Lee, P. Wiriyasermkul, C. Jin, L. Quan, R. Ohgaki, S. Okuda, T. Kusakizako, T. Nishizawa, K. Oda, R. Ishitani, T. Yokoyama, T. Nakane, M. Shirouzu, H. Endou, S. Nagamori, , O. Nureki

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

bioRxiv · Mar 14, 2019Biochemistry