Y. Li

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

This study shows MyD88 is essential for M cell differentiation in colitis and RANKL-induced conditions in mice.

This study shows drought reduces sucrose transport from cottonseed coat to fiber and disrupts sucrose allocation, leading to decreased cellulose synthesis and fiber strength.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This study shows that transplanting bacteriophages from UC patients alters gut bacteria and worsens colitis in mice.

The paper identifies a unique sulfotransferase-involving strigolactone biosynthetic pathway in sorghum involving SbMAX1d and LGS1.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.

The paper shows serine starvation reduces ER expression and histone acetylation in breast cancer cells, linking metabolic stress to chromatin changes and ER pathway inactivation.

This study identifies co-infection events of SARS-CoV-2 lineages in genomic data, finding 53 events across 29,993 samples, including one triple lineage infection, and notes an increasing trend with viral diversity.

This study identifies Vinigrol as a broad-spectrum anti-cancer agent that activates the PERK/eIF2 arm of the UPR via ATF4/DDIT3 to induce breast cancer cell death.

The paper examines how repeated micropollutant exposure affects microbial community succession and degradation patterns in freshwater systems.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

This study shows that soil inoculum origin and amount affect microbiome and plant community development in degraded grasslands over three years.

The paper develops a tumor-specific method to detect allelic imbalances for HRD prediction, showing improved clinical outcome prediction in ovarian and breast cancers.

This study shows ATP6AP2 is essential for endothelial cell polarity and extracellular matrix production during both normal and disease-related blood vessel growth.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This study identifies a novel MarR subfamily, MarRars, that regulates arsenic resistance genes by responding to As(III) and Sb(III) and repressing arsV expression.

This study shows genetic compensation in Chlamydomonas reinhardtii for triacylglycerol biosynthesis genes under stress, with PDAT compensating DGTT1 knockout and maintaining lipid homeostasis.

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study identifies a pyroptosis-related molecular classification and prognostic signature for glioma using integrative analysis of genomic and clinical data.

This study identifies three conserved hydrophobic residues in the CC domain of rice NLR Pit that contribute to plasma membrane localization and immune induction, distinct from their roles in other NLRs.

This study identifies two genetic variants associated with pancreatic fat content and suggests a potential link between pancreatic fat and type 2 diabetes.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This paper identifies the molecular mechanism of Jin Ning Fang's anti-lung cancer effect using network pharmacology and experimental validation, revealing key targets and compounds involved.

The paper investigates how herbivory and nutrient availability fluctuations interact to affect alien plant dominance in synthetic communities.

This study identifies rhizosphere metabolites and microbial shifts in alfalfa soils under continuous cropping, showing autotoxic substances like p-coumaric acid contribute to crop obstacles.