Y. Li

The paper improves the reference genome annotation of Brassica rapa using PacBio RNA sequencing, identifying novel genes, correcting splicing errors, and characterizing alternative splicing and lncRNAs.

This paper develops a novel glycoengineering platform, MAGIC, which increases glycoconjugate yield and enables vaccine development in genetically intractable bacteria.

The paper identifies a mutational mechanism in hepatocellular carcinoma driven by Hepatitis B virus DNA integration, leading to genomic restructuring and oncogenic rearrangements.

This study uses ribosome profiling to analyze PRRSV gene expression and reveals temporally regulated frameshifting and novel transcripts.

The paper investigates age-dependent H3K9 acetylation changes in rice flag leaf senescence, finding increased H3K9ac levels correlate with gene expression and identify regulatory networks.

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

The paper shows that age-induced P-bodies in yeast shorten lifespan and are detrimental, with cytosol acidification exacerbating this effect.

The paper identifies PIRAT, a lncRNA regulating monocyte immunity in COVID-19 via PU.1 feedback, and shows its role in alarmin production.

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

OrthoSNAP identifies single-copy orthologs from gene family trees, increasing the number of markers for molecular evolution studies by splitting and pruning gene families.

This paper introduces a ratiometric multi-color imaging strategy for 4Pi-SMLM that achieves optimal 3D resolution and color separation with minimal loss of localization precision.

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

This study identifies ZFP36L1 as an LSD1 target gene that regulates neuroendocrine plasticity in SCLC by destabilizing mRNAs of lineage transcription factors.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This study identifies a 4-analyte serum panel to detect radiation exposure in nonhuman primates using multi-omics data from mass spectrometry.

This study shows pVHL regulates TCF/LEF protein stability via ubiquitin-independent proteasomal degradation, revealing a novel mechanism in Wnt/β-catenin signaling.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study investigates how humans weigh different information sources during goal-directed decision making, finding that accurate decision-makers balance relevant constraints more effectively.

The paper investigates the origin and function of the STORR gene fusion in Papaver species, finding it occurred once between 17-25 million years ago and is not exclusive to morphinan production.

This study shows that CD47 cross-dressing via extracellular vesicles inhibits phagocytosis without causing cell death, offering a safer alternative to CD47 overexpression.

This paper develops a split-nCas9 system using intein-mediated reassembly for efficient base editing in plants.

This paper demonstrates the use of cationic lipid nanoparticles to deliver engineered antibodies into cells, enabling selective disruption of intracellular signaling via pYSTAT3.

This study evaluates the effect of Idesia polycarpa fruit residues fermented feed additive on laying quail egg production and related performance metrics, finding improved egg production, reduced cholesterol, and enhanced lipid metabolism.

This study examines mosquito resistance to PBO-synergized pyrethroids and finds that field mosquitoes are resistant despite PBO exposure, due to elevated metabolic enzyme levels and knockdown resistance mutations.

This paper identifies KIF4 as a critical regulator of NTCP surface localization for HBV/HDV entry and shows RXR agonists can suppress KIF4 to inhibit viral infection.

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.