Y. Peng

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

This study shows that endothelial PHD2 deficiency leads to nitrative stress via suppression of Caveolin-1, contributing to pulmonary arterial hypertension and vascular remodeling.

This study constructs a ceRNA network in metastatic melanoma to identify prognostic markers and therapeutic targets, finding miR-3662 may be used in treatment.

This study shows pro-inflammatory cytokines TNF and IL-6 enhance Treg proliferation without compromising their function or lineage identity.

The paper identifies horizontal gene transfer as a driver of convergent evolution in Arctic microalgae, highlighting ice-binding domain gene transfers between distantly related species.

The paper uses molecular dynamics simulations to show that DNA methylation at CpG sites alters nucleosome geometry, stability, and unwrapping behavior.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study shows that IGF-1C and P24 together enhance osteogenic differentiation of BMSCs by activating p38 and JNK pathways.

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

This study meta-analyzes 193 studies to compare single visit pollination effectiveness across plant visitors, finding honeybees are less effective than many non-honeybee pollinators.

This study shows that two rice pests, the brown planthopper and the rice striped stem borer, cooperate by jointly attacking rice plants, improving plant quality and reducing parasitism risk.

This study shows TPD52 inhibits AMPK activity, leading to metabolic defects in mice, highlighting its role in cancer metabolism.

This study shows that gut microbiota in Anopheles stephensi affects tryptophan metabolism, with Pseudomonas alcaligenes reducing 3-HK to protect against Plasmodium infection.

This study identifies JAM2 as a prognostic marker and potential predictor of immunotherapy response in breast cancer using multi-database analysis.

The paper uses molecular dynamics simulations to study how histone tails modulate nucleosome DNA accessibility and protein binding, revealing distinct binding modes and competitive interactions.

This paper develops a whole-genome MLST (wgMLST) scheme for Bordetella pertussis to improve molecular typing and genomic surveillance, revealing greater resolution in population structure and outbreak analysis.

The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.

This study identifies a Krt5-BMP4 mechanosignaling pathway that regulates histone modifications and blastema cell remodeling during zebrafish heart regeneration.

The paper analyzes viral diversity in deep sea cold seep sediments, finding high endemism and links to microbial hosts and biogeochemical cycling.

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

The paper measures physical properties of mouse meiotic prophase I chromosomes, finding they are stiffer than mitotic chromosomes and have a gel-like chromatin organization.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

The paper examines the expression of SARS-CoV-2-related molecules in human tissues and immune cells across health and disease states, identifying age, comorbidities, and immune cell types associated with altered expression.

This study identifies increased p53 signaling as the cause of impaired neural differentiation in HUWE1-promoted XLIDs, showing that reducing p53 levels rescues neurodevelopmental defects.