Y. Shen

This study examines SARSr-CoV-2 in Malayan pangolins, showing lung infection, vertical transmission, and immune response similarities to COVID-19 in humans.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

This study shows immune selection pressure in pancreatic cancer drives myeloid mimicry and immune evasion, which can be counteracted by JAK/STAT pathway inhibition to enhance immunotherapy.

This study introduces PORE-cupine, a method combining structure probing and nanopore sequencing to detect RNA secondary structures, revealing isoform-specific structural differences and their impact on translation efficiency.

The paper describes the atomic-level interaction between a bacteriophage endolysin's CBD500 domain and Listeria cell wall teichoic acid, identifying key epitopes and binding mechanisms.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.

This paper presents a CAD system for pulmonary nodule detection that improves recall, reduces false positives, and optimizes time consumption using a multi-model ensemble approach.

This paper develops an oral SARS-COV-2 RBD vaccine using LTB26 adjuvant in mice, showing enhanced antibody production and immune activation through DCs and B cells.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

This paper shows that HCFC1 and HCFC1R1 deficiencies block HSV-1 infection by inhibiting nuclear translocation of HCFC1 and VP16, offering potential new therapeutic targets.

This study shows that Nrf2 represses ER stress-related ferroptosis in renal carcinoma cells through the HO-1 pathway, suggesting it as a potential therapeutic target.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

SMART-Q quantifies cell type-specific RNA transcripts by integrating smFISH data with cell identity information from immunostaining.

The paper demonstrates that antibiotic-resistant cells can be inhibited by exploiting fitness trade-offs using norvaline to target genetic mutations in leucyl-tRNA synthetase in tavaborole-resistant E. coli.

This study shows IL-22 improves liver injury by promoting metabolic reprogramming and mitochondrial function through a signaling pathway involving AMPK, AKT, and mTOR.

This paper shows that GtcA is essential for LTA glycosylation in L. monocytogenes and B. subtilis and suggests it functions as a C55-P-sugar flippase.

This study examines how zinc and calcium ions affect the structure and mechanics of vimentin intermediate filaments, showing that zinc is more effective at lower concentrations and that ion binding can compete.

This study develops a mouse model of glioblastoma (GBM) that replicates its genomic landscape and early stages, enabling research into prevention and treatment strategies.

This study evaluates open versus closed hollow hydroxyapatite microspheres for bone regeneration in rat calvarial defects, finding open microspheres promote greater bone regeneration, especially at smaller sizes.

The paper reports the crystal structure and cryo-EM reconstruction of a constitutively active Drosophila Orai mutant, revealing the molecular mechanism of channel activation and Ca2+ permeation.

This study shows BBB dysfunction in aging leads to TGF-beta hyperactivation in astrocytes, causing neural dysfunction, which can be reversed by inhibiting TGF-beta signaling.

This study examines how seasonal environmental changes affect the diet and toxin profiles of Climbing Mantella frogs, finding seasonal differences in diet composition and toxin abundance.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

The paper analyzes nine red GECIs to determine the factors causing Ca2+-dependent fluorescence changes, finding three distinct classes based on their mechanisms.

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

This study shows that bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by inhibiting Y537S and D538G ER mutants more effectively than tamoxifen.

This paper introduces DO-SRS, a method to visualize metabolic dynamics in living tissues by imaging deuterium incorporation into macromolecules.

The paper develops and validates a new red fluorescent calcium indicator, K-GECO1, based on a circularly permutated RFP from a sea anemone, tested across multiple cell types and organisms.

This study identifies 208 imprinted genes in rice, showing limited transposable element association, intraspecific variation, and conservation of imprinting at some loci across plant species.