J. Zhai

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

This study develops rod-shaped Janus base nanopieces for improved tissue penetration and therapeutics delivery, showing better efficacy than spherical lipid nanoparticles in ovarian cancer models.

A Day in the Life of Arabidopsis: 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms

This study uses snRNA-seq to analyze circadian rhythms in Arabidopsis over 24 hours, revealing cell-type specific gene expression patterns and identifying key circadian regulators.

Comparative single-nucleus RNA-seq analysis captures shared and distinct responses to beneficial and pathogenic microbes in roots

The paper uses single-nucleus RNA-seq to compare plant root responses to beneficial and pathogenic microbes, identifying triterpene biosynthesis as a novel response to pathogens.

FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule symbiosis establishment

The paper integrates single-nucleus and spatial transcriptomics to map transitional states in soybean nodule symbiosis, identifying functionally distinct cell subgroups and a transitional infected cell subtype.

Plant Intron Splicing Efficiency Database (PISE): exploring splicing of ~1,650,000 introns in Arabidopsis, maize, rice and soybean from ~57,000 public RNA-seq libraries

The paper creates a database of intron splicing efficiency across multiple plant species using public RNA-seq data to explore how splicing varies with treatments and genetic mutants.

PPRD: a comprehensive online database for expression analysis of ~45,000 plant public RNA-Seq libraries

PPRD integrates and curates ~45,000 plant RNA-seq libraries into a searchable database to facilitate expression analysis.

Interactive Web-based Annotation of Plant MicroRNAs with iwa-miRNA

The paper introduces iwa-miRNA, a web-based tool for interactive annotation of plant miRNAs using sRNA-Seq data and manual curation.

Introducing undergraduate students to reverse genetics in the laboratory: a case study of a project-oriented learning (POL) system in Taishan Medical University, China

This paper describes a project-oriented learning system at Taishan Medical University that uses reverse genetics to enhance undergraduate students' understanding of biochemistry and molecular biology through hands-on laboratory experience.

Substrate deformation regulates DRM2-mediated DNA methylation in plants

This study identifies DNA deformation as a mechanism regulating DRM2-mediated methylation specificity in plants, showing how substrate deformation influences substrate preference.

Isolation and Characterization of 2019-nCoV-like Coronavirus from Malayan Pangolins

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

Cis-directed cleavage and nonstoichiometric abundances of 21-nt reproductive phasiRNAs in grasses

The paper characterizes 21-nt reproductive phasiRNAs in grasses, showing cis-directed cleavage and nonstoichiometric abundance patterns in rice and maize.