Y. Yan

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

The paper examines the genomic bases of ecological diversification in core landbirds, identifying adaptive enhancements in diet and vision related to their lifestyles.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study investigates the molecular mechanisms of 2019-nCoV binding to human ACE2 and its evolutionary advantages over SARS-CoV using computational methods.

The paper identifies a stress-like cancer cell state in melanoma that promotes tumorigenesis and drug resistance, validated across zebrafish and human models.

This meta-analysis examines the impact of postoperative radiotherapy waiting time on high-grade glioma prognosis and finds no significant association with overall survival.

This study examines how wrinkle structures in the veins of Asian ladybird hind wings affect deformation and flight performance, suggesting bioinspiration for micro air vehicle wing design.

The paper investigates correlated evolution of large DNA fragments in the 3D genome of Arabidopsis thaliana, showing that spatially interacting fragments exhibit similar polymorphism and evolutionary rates.

This study shows that rabies virus glycoprotein suppresses gastric cancer migration by inhibiting the 7-nAChR-MEK/ERK-EMT pathway.

This paper tests four picornaviral 2A peptides for co-expression and differential localization of proteins in insect cells and Drosophila suzukii, finding that EGFP-CAAX can be bred to homozygosity while DsRed-CAAX is lethal.

The paper develops novel inhibitors targeting DHFR enzymes in MRSA to overcome trimethoprim resistance, showing low nanomolar activity and human selectivity.

This paper identifies how FICD switches between AMPylation and deAMPylation of BiP by changing its oligomeric state, regulated by ATP/ADP levels.

The paper introduces a modified ABE method that reduces background noise in S-acylproteomic analysis, enabling the identification of 2,895 high-confidence S-acylated proteins in human prostate cancer cells.

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.

The paper analyzes genomic data from 1,103 Vibrio parahaemolyticus isolates to show recent genetic mixing among four populations due to increased human-mediated dispersal.

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

This study identifies deregulated protein complexes in prostate cancer tissues using quantitative proteomics and reveals differences between low-grade and high-grade prostate cancer.