Y. Yan

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

This paper introduces OligoArchive-DSM, a DNA-based data archival system that reduces costs while tolerating errors through columnar encoding and integrated decoding.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

This study identifies H2BFWT's role in spermatogenesis by showing its impact on nucleosome stability and gene expression through structural and functional analyses.

The paper validates on-target and off-target effects of anti-Cryptosporidium drugs using a novel MDR1-transgenic host cell model and algorithms to quantify drug action contributions.

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

This study investigates the structural and biochemical basis of early FER receptor kinase signaling in Arabidopsis, revealing an active conformation and the role of Tyr phosphorylation in substrate activation.

The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.

The paper identifies the IMD and JNK pathways as regulators of immune-circulatory integration in mosquitoes through RNAseq and RNAi experiments.

This study identifies OsDML4 as a demethylase gene whose knockout under high temperature causes floury endosperm by altering DNA methylation and gene expression in rice.

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.

The paper shows that NOTCH1 variation within microtumors enhances invasiveness, linking intratumoral heterogeneity to collective cancer invasion.

This study investigates how ionic strength affects HU protein-induced DNA supercoiling and compaction using single-molecule techniques.

This study examines how nutrient enrichment and herbivory by an invasive snail interactively affect growth of an invasive macrophyte and native macrophytes in freshwater mesocosms.

This study proposes a co-sparse analysis model for registering intra-operative photoacoustic images with pre-operative MR images to improve brain shift compensation in neurosurgery.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

The paper presents a Cryo-EM structure of the PP1c/PPP1R15A/G-actin complex that terminates the Integrated Stress Response by positioning eIF2's phosphoserine-51 at the active site.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study identifies MARCH1 and MARCH8 as specialized regulators of CD4+ T cell immunity in distinct cellular compartments by analyzing their substrates and expression in mice.

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

The paper shows that positive supercoiling helps RNA polymerase bypass LacI-mediated DNA loops in E. coli by reducing pauses and enhancing dissociation of roadblocks.

The paper shows that negative DNA supercoiling reduces stochasticity in protein-mediated DNA looping, making it deterministic and ergodic within bacterial doubling time.

This study shows that the intrinsic movement order of voltage-sensing domains in Nav channels determines their susceptibility to regulation by β1 and β3 subunits, explaining variable regulatory effects across channel isoforms.

This study evaluates the impact of different sterilization methods on the properties of a conjugated polymer-based bioelectronic patch, finding that ethylene oxide and low-dose gamma irradiation best preserve its performance and minimize immune response.

This study identifies GajA as a nucleotide-regulated endonuclease from the Gabija bacterial defense system, which is inhibited by NTP and dNTP but activated during phage infection.

This study evaluates the effects of chronic bioelectric nerve stimulation on neuroskeletal health in diabetic rats, finding it does not prevent neuropathy or musculoskeletal complications but affects bone density and gait.