Author

Z. Sebestyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Kuball· 3 shared A. D. Meringa· 2 shared H. Clevers· 2 shared I. Johanna· 2 shared K. Kretzschmar· 2 shared S. Heijhuurs· 2 shared Y. E. Bar-Ephraim· 2 shared A. C. Rios· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

J. Kuball

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Engineering BCMA CAR T cells for myeloma-targeted cargo delivery

T. Kimman, M. Cuenca, A. Slomp, R. G. Tieland, D. Rockx-Brouwer, S. Heijhuurs, A. D. Meringa, W. Boschloo, D. M. Bosma, S. Kroos, V. lo Presti, S. Nierkens, N. Bovenschen, J. Kuball, M. C. Minnema, , V. Peperzak

This paper develops BCMA CAR T cells with a granzyme B-NOXA fusion to enhance apoptosis in multiple myeloma cells, improving killing efficacy in vitro and in xenograft models.

bioRxiv · Feb 14, 2024 · PreprintImmunology

Behavioral-transcriptomic landscape of engineered T cells targeting human cancer organoids

J. F. Dekkers, M. Alieva, A. Cleven, F. Keramati, P. Brazda, H. G. Rebel, A. K. L. Wezenaar, J. Puschhof, M.-B. Buchholz, M. Barrera Roman, I. Johanna, A. D. Meringa, D. Fasci, M. H. Geurts, H. C. R. Ariese, , A. C. Rios

The paper develops BEHAV3D, a 3D imaging-transcriptomics platform to study T cell behavior and molecular mechanisms in cancer organoids, identifying a super engager cluster with unique gene signatures and IFN-I priming capabilities.

bioRxiv · May 5, 2021Cancer Biology

Enhancing cancer targeting of γ9δ2TCR through modified NKG2D co-stimulation

P. Hernandez-Lopez, E. van Diest, I. Johanna, S. Heijhuurs, T. Straetemans, Z. Sebestyen, D. X. Beringer, J. Kuball

This paper improves the antitumor activity of TEG001 by co-expressing NKG2D-based chimeric co-receptors with the {gamma}{delta}TCR-Cl5.

bioRxiv · Jan 6, 2021 · PreprintImmunology

Modelling cancer immunomodulation using epithelial organoid cultures

Y. E. Bar-Ephraim, K. Kretzschmar, P. Asra, E. de Jongh, K. E. Boonekamp, J. Drost, J. van Gorp, A. Pronk, N. Smakman, I. J. Gan, Z. Sebestyen, J. H. Kuball, R. G. Vries, H. Clevers

This study uses CRC organoids to model immune-cancer interactions and assess immunomodulation by co-culturing with cytotoxic T cells.

bioRxiv · Oct 4, 2018 · PreprintCancer Biology