Organelle phenotyping and multi-dimensional microscopy identify C1q as a novel regulator of microglial function.
Pooja S. Sakthivel, Lorenzo Scipioni, J. D. Karam, Zahara Keulen, Mathew M. Blurton-Jones, Enrico Gratton, Aileen J. Anderson
The paper introduces an organelle phenotyping approach using live-cell microscopy to identify C1q as a regulator of microglial function, showing its role in fatty acid storage and mitochondrial membrane potential.
Journal of Neurochemistry · Jul 17, 2024Peer-reviewedNeuroscience