David D. Gonda

The contribution of de novo coding mutations to meningomyelocele

The paper identifies de novo mutations contributing to meningomyelocele risk by analyzing trios and finding damaging mutations in 22.3% of cases.

The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma

The paper identifies sex differences in microglial inflammatory responses in glioblastoma, showing that genes on the inactive X chromosome drive these differences.

Comprehensive multiomic profiling of somatic mutations in malformations of cortical development

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

Gene regulatory networks underlying human microglia maturation

This study defines age-specific brain environmental factors driving microglia phenotypes through transcriptomic and epigenomic analysis of human fetal and postnatal microglia.

Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk association

The paper identifies cell type-specific enhancer-promoter connectivity in the human brain and links these to disease risk variants in Alzheimer's and psychiatric disorders.