John A. Lemen

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.