Author

Ruud Delwel

Erasmus MCORCID 0000-0001-6903-3271Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2

Frequent Co-Authors

Roger Mulet‐LazaroiD· 3 shared Claudia A. J. Erpelinck-VerschuereniD· 2 shared Claudia GebhardiD· 2 shared Leonie SmeenkiD· 2 shared Torsten HaferlachiD· 2 shared Aaron D. VinyiD· 1 shared Alexander Fisher· 1 shared Anabella Maria D. GalangiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Roger Mulet‐LazaroORCID

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4 papers

Recent·Most cited

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia

Dorien Pastoors, Marije Havermans, Roger Mulet‐Lazaro, Leonie Smeenk, Sophie Ottema, Claudia A. J. Erpelinck-Verschueren, Stanley van Herk, Maikel Anthonissen, Tim Grob, Shruthi Subramanian, Julie A.I. Thoms, John E. Pimanda, Bas J. Wouters, H. Berna Beverloo, Torsten Haferlach, , Ruud Delwel

This study shows MECOM represses myeloid differentiation by inhibiting CEBPA, and its overexpression in AML reduces CEBPA levels, maintaining stem cell state.

Blood · Oct 8, 2025Peer-reviewedCancer Biology

Altered chromatin accessibility mediated by somatic cohesin mutations amplifies FLI1-Menin output to promote leukemogenesis

Jane Jialu Xu, Viviana Scoca, Yi Chen, Yingqian Ada Zhan, Alexander Fisher, Eno-obong Udoh, Sebastian Fernando, Besmira Alija, John Pantazi, Varun S. Sudunagunta, Edna Stewart, Anabella Maria D. Galang, Michael Williams, Govind Bhagat, Claudia Gebhard, , Aaron D. Viny

This study shows that cohesin mutations alter chromatin accessibility, enhancing FLI1-Menin interaction and promoting leukemogenesis through therapeutic vulnerabilities.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q

Etienne Sollier, Anna Riedel, Umut H. Toprak, Justyna A. Wierzbińska, Dieter Weichenhan, Jan Philipp Schmid, Mariam Hakobyan, Aurore Touzart, Ekaterina Jahn, Binje Vick, Fiona Brown-Burke, Katherine A. Kelly, Simge Kelekçi, Anastasija Pejkovska, Ashish Goyal, , Christoph Plass

Pyjacker detects enhancer hijacking in AML, identifying MNX1 activation via 7q deletion as a novel oncogenic mechanism.

Blood Cancer Discovery · Mar 31, 2025Peer-reviewedCancer Biology

A Novel XACT lncRNA Transcript with Functions Transcending X-Chromosome Inactivation.

Pei‐Fen Zhang, Paula Haro Angles, Hong Zhang, Tingyue Li, Roger Mulet‐Lazaro, Wilfred F. J. van IJcken, Sjaak Philipsen, Ruud Delwel, Joost H. Gribnau, Danny Huylebroeck, Frank G. Grosveld, Claire Rougeulle, Eskeatnaf Mulugeta

The paper identifies a novel XACT lncRNA transcript expressed in both active and inactive X chromosomes, with roles in erythroid differentiation and AML subtypes beyond its role in XCI.

bioRxiv · Jan 3, 2025 · PreprintGenetics