Author

Guillaume Mestrallet

Tisch Cancer InstituteORCID 0000-0002-9514-313XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

Nina BhardwajiD· 3 shared Aparna AnanthanarayananiD· 2 shared Cansu Cimen BozkusiD· 2 shared Jesse BoumelhaiD· 2 shared Matthew BrowniD· 2 shared Miriam MéradiD· 2 shared Natalie VaninoviD· 2 shared Nicolas VabretiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

Nina BhardwajORCID

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4 papers

Recent·Most cited

Epigenetic profile drives accurate survival prediction in breast cancer via a multi-omics machine learning model

Guillaume Mestrallet, Alexandre Pierga, Paul Frémont

This paper develops a multi-omics machine learning model to predict breast cancer survival, finding that epigenetic features are the strongest predictors.

Peer Community Journal · Jul 22, 2026Peer-reviewedCancer Biology

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

Raphaël Mattiuz, Jesse Boumelha, Emmanouil Aerakis, Jessica Le Bérichel, Pauline Hamon, László Halász, Abishek Balachandra Vaidya, Brian Y. Soong, Emir Radkevich, Hye Mi Kim, Matthew D. Park, Romain Donné, Leanna Troncoso, Rachel A. Kaplan, Clotilde Hennequin, , Miriam Mérad

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

Science · Jul 16, 2026Peer-reviewedImmunology

Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancer.

Guillaume Mestrallet, Matthew Brown, Natalie Vaninov, Nam Woo Cho, Leandra G. Velazquez, Aparna Ananthanarayanan, Matthew H. Spitzer, Nicolas Vabret, Cansu Cimen Bozkus, Robert M. Samstein, Nina Bhardwaj

This study identifies T cell and macrophage subsets that mediate response to anti-PD-1 therapy in colorectal cancer, showing that combination therapy can eradicate tumors in both MMRd and MMRp settings.

Cell Reports Medicine · May 1, 2026Peer-reviewedImmunology

Targeting neoantigens conserved across organs and species overcomes tumor immune escape

Guillaume Mestrallet, Ross W. Ward, Matthew Brown, Jesse Boumelha, Frederika Rentzeperis, Natalie Vaninov, Miriam Saffern, Ezekiel Olumuyide, Prerna Suri, Sreekumar Balan, Leandra Velazquez, Aparna Ananthanarayanan, Zhihong Chen, Aimee L. Lucas, Miriam Mérad, , Nina Bhardwaj

This study identifies conserved neoantigens across species and tissues that elicit strong immune responses and suppress tumor growth through vaccination.

bioRxiv · Sep 25, 2025 · PreprintImmunology