Author

Tencho Tenev

Institute of Cancer ResearchORCID 0000-0001-8762-1069Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Tencho Tenev1 paper · Imperial College London

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Pascal MeieriD· 3 shared Rebecca Wilson· 2 shared Agnieszka KonopackaiD· 1 shared Alessandro Ori‬‬iD· 1 shared Andrea ScarpinoiD· 1 shared Ari SatanowskiiD· 1 shared Bachuki ShashikadzeiD· 1 shared Benjamin R. BellenieiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

Pascal MeierORCID

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Author profile →

3 papers

Recent·Most cited

Developing Potent and Selective TBK1 Molecular Glue Degraders for Cancer Immunotherapy

John Caldwell, Patrick R. A. Zanon, Iona Ferguson, Stephen T. Hallett, Tencho Tenev, Natalia Serrano-Aparicio, Russell J.H. Wood, Shakil Khan, Sidonie Wicky John, Rebecca Wilson, Matthew T. Warren, P. Craig McAndrew, Martin Steger, Denise Winkler, Uli Ohmayer, , Zoran Ranković

This paper develops a first-in-class TBK1 molecular glue degrader, CCT412020, which enhances anti-tumour immunity and overcomes immune checkpoint blockade resistance.

bioRxiv · Feb 2, 2026 · PreprintCancer Biology

RIPK1 is essential for Herpes Simplex Virus-triggered ZBP1-dependent necroptosis in human cells

Oluwamuyiwa T. Amusan, Shuqi Wang, Chaoran Yin, Heather S. Koehler, Yixun Li, Tencho Tenev, Rebecca Wilson, Benjamin R. Bellenie, Ting Zhang, Jian Wang, Chang Liu, Kim Seong, Seyedeh Leila Poorbaghi, Joseph Yates, Yuchen Shen, , Hongyan Guo

This study shows that RIPK1 is essential for ZBP1-dependent necroptosis in human cells but not in mice, highlighting a species-specific mechanism.

PLoS Biology · Feb 21, 2025Peer-reviewedCell Biology

Novel biochemical, structural and systems insights into inflammatory signaling revealed by contextual interaction proteomics

Rodolfo Ciuffa, Federico Uliana, Jonathan Mannion, Martin Mehnert, Tencho Tenev, Cathy Marulli, Ari Satanowski, Lena Maria Leone Keller, Pilar Natalia Rodilla-Ramírez, Alessandro Ori‬‬, Matthias Gstaiger, Pascal Meier, Ruedi H. Aebersold

The paper presents an integrated experimental and computational strategy to model protein-protein interactions in cellular context, applied to the TNF-receptor signaling complex.

Proceedings of the National Academy of Sciences · Sep 30, 2022Peer-reviewedSystems Biology