Jeramie D. Watrous

Pulmonary primary oxysterol and bile acid synthesis as a predictor of outcomesin pulmonary arterial hypertension

The paper identifies pulmonary primary oxysterol and bile acid synthesis as a prognostic biomarker for pulmonary arterial hypertension, outperforming current clinical risk scores.

Rapid Liquid Chromatography-Mass Spectrometry (rLC-MS) for Deep Metabolomics Analysis of Population Scale Studies

The paper introduces a high-throughput rLC-MS system for metabolomics analysis, demonstrating its ability to capture metabolic variation in large human populations and predict metabolic aging.

Isotope tracing-based metabolite identificationfor mass spectrometry metabolomics

This paper introduces a method using isotope tracing and mass isotopomer distributions to identify novel metabolites in mass spectrometry data, achieving 62% identification of unknown peaks.

Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms

This study identifies ether lipid biosynthesis as a key pathway mediating the longevity benefits of biguanides like metformin in C. elegans.

Genome-wide association and Mendelian randomization analysis prioritizes bioactive metabolites with putative causal effects on common diseases

This study identifies 118 genetic loci associated with 2,319 metabolite features and finds 46 causal effects of metabolites on common diseases using genome-wide association and Mendelian randomization.

MASST: A Web-based Basic Mass Spectrometry Search Tool for Molecules to Search Public Data.

MASST enables querying of public small-molecule tandem MS data to discover molecular relationships in metabolomics and natural product datasets.