Roger J. Thompson

Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes

This study identifies that PANX1 Y198 phosphorylation mediates ATP release, driving β-adrenergic vasoconstriction in vascular smooth muscle cells.

A sensitive orange fluorescent calcium ion indicator for imaging neural activity

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

Contralesional hippocampal spreading depolarization promotes functional recovery after stroke

This study shows that contralesional hippocampal spreading depolarization improves functional recovery after hippocampal stroke in mice.

The Pannexin-1 N-terminal Helix Gates a Switch between Ion Conductance and Anandamide Transport

The paper investigates the dual function of pannexin-1 as an ion channel and anandamide transporter, showing that the N-terminal helix regulates this switch.

A Genetic Variant of Fatty Acid Amide Hydrolase (FAAH) Exacerbates Hormone- Mediated Orexigenic Feeding in Mice

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

The paper shows that astrocyte Ca2+ signaling amplifies sustained functional hyperemia in awake mice, but not brief responses, through distinct mechanisms.

Shadow imaging for panoptical visualisation of living brain tissue

This paper introduces a method to visualize living brain tissue in real-time with high anatomical detail using light microscopy and fluorescence labeling of interstitial fluid.

TRPV1 regulates opioid analgesia during inflammation

The paper shows TRPV1 channels enhance opioid analgesia during inflammation by promoting beta-arrestin2 nuclear translocation, preventing receptor desensitization.

Postsynaptic Pannexin-1 Facilitates Anandamide Uptake to Modulate Glutamate Release and Enhance Network Excitability

This study shows that postsynaptic pannexin-1 regulates glutamate release and network excitability by facilitating anandamide clearance and modulating TRPV1 activity.