Author

Vincenzo Bonifati

Erasmus MCORCID 0000-0002-9334-1263Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Assay:imaging· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Wim J. MandemakersiD· 4 shared Ana Carreras MascaroiD· 3 shared Federico FerraroiD· 3 shared Guido J. BreedveldiD· 3 shared Valerie Boumeester· 3 shared Angela M. T. IngrassiaiD· 2 shared Evelien Huisman· 2 shared Frank Jan de JongiD· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersNeuroscience

Wim J. MandemakersORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

DJ-1 mediates regulation of metabolism and immune response in Parkinsons disease astrocytes and Glioblastoma cells

Pauline Mencke, Jochen Ohnmacht, Félicia Jeannelle, Adrien J Ries, Mónica Miranda de la Maza, Mathilde M. Ullrich, François Massart, Patrycja Mulica, Katja Badanjak, Zoé Hanss, Arkadiusz Rybicki, Paul M. A. Antony, Sylvie Delcambre, Giuseppe Arena, Gérald Cruciani, , Ibrahim Boussaad

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

bioRxiv · Oct 31, 2024 · PreprintNeuroscience

Interactome mapping reveals a role for LRP10 in autophagy and NDFIP1-mediated alpha-synuclein secretion

Ana Carreras Mascaro, Federico Ferraro, Valerie Boumeester, Guido J. Breedveld, Dick H. W. Dekkers, Leonie J.M. Vergouw, Frank Jan de Jong, Jeroen Demmers, Vincenzo Bonifati, Wim J. Mandemakers

This study identifies LRP10 interactors and pathways, showing its role in autophagy and NDFIP1-mediated alpha-synuclein secretion, with differences between LRP10-WT and LRP10-Splice variants.

bioRxiv · Nov 28, 2023 · PreprintNeuroscience

Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and GBA-related Parkinson's disease and Dementia with Lewy bodies

Tim E. Moors, Martino L. Morella, Cesc Bertran-Cobo, Hanneke Geut, Vinod Udayar, Evelien Huisman, Angela M. T. Ingrassia, John J. P. Brevé, John G. J. M. Bol, Vincenzo Bonifati, Ravi Jagasia, Wilma D. J. van de Berg

The paper examines TFEB subcellular localization in Parkinson's and Lewy body disease brains, finding altered distribution linked to disease stages and GBA variants.

bioRxiv · Jul 16, 2023 · PreprintNeuroscience

LRP10 as a novel α-synuclein regulator in Lewy body diseases

Ana Carreras Mascaro, Martyna M. Grochowska, Valerie Boumeester, Natasja F. J. Dits, Ece Naz Bilgiҫ, Guido J. Breedveld, Leonie J.M. Vergouw, Frank Jan de Jong, Martin E. van Royen, Vincenzo Bonifati, Wim J. Mandemakers

This study investigates the role of LRP10 in Lewy body diseases, showing it regulates α-synuclein levels and interacts with a disease-associated variant.

bioRxiv · May 12, 2023 · PreprintNeuroscience

deCLUTTER2+ pipeline to analyze calcium traces in a novel stem cell model for ventral midbrain patterned astrocytes

Martyna M. Grochowska, Federico Ferraro, Ana Carreras Mascaro, Domenico Natale, Amber B Winkelaar, Valerie Boumeester, Guido J. Breedveld, Vincenzo Bonifati, Wim J. Mandemakers

The paper introduces a new pipeline for analyzing calcium traces in a stem cell model of ventral midbrain astrocytes, enabling functional characterization under physiological and PD conditions.

bioRxiv · Nov 8, 2022 · PreprintNeuroscience

Correcting differential gene expression analysis for cyto-architectural alterations in substantia nigra of Parkinson's disease patients reveals known and potential novel disease-associated genes and pathways

Federico Ferraro, Christina Fevga, Vincenzo Bonifati, Wim J. Mandemakers, Ahmed Essam Mahfouz, Marcel J. T. Reinders

Cells · Jan 7, 2022Peer-reviewedBioinformatics

Lewy pathology in Parkinson's disease consists of a crowded organellar, membranous medley

Sarah H. Shahmoradian, Amanda J. Lewis, Christel Genoud, Jürgen Hench, Tim E. Moors, Paula P. Navarro, Daniel Castaño‐Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N. Goldie, Rosmarie Sütterlin, Evelien Huisman, Angela M. T. Ingrassia, Yvonne de Gier, Annemieke J.M. Rozemüller, , Matthias E. Lauer

The paper uses high-resolution imaging and biophysical methods to show that Lewy pathology in Parkinson's disease consists mainly of a crowded membranous medley of vesicles and dysmorphic organelles, with only a small fraction containing proteinaceous filaments.

Nature Neuroscience · Jun 24, 2019Peer-reviewedNeuroscience