Gregory S.X.E. Jefferis

Flood-filling networks with local section realignment segment a forty-teravoxel whole-brain Drosophila electron microscopy volume, making circuit reconstruction an order of magnitude faster than manual tracing.

The paper presents a detailed connectome of the adult Drosophila central brain, including new methods for data analysis and biological insights into neural circuit organization.

The paper maps the synaptic connectivity of the Drosophila mushroom body and identifies new circuit components and structures in sensory input processing and output modulation.

The paper reconstructs the complete connectome of olfactory projection neurons in the Drosophila brain and identifies new connectivity patterns in olfactory circuits.

The paper identifies anatomical subtypes of dopaminergic neurons in Drosophila and their specific input connectivity, revealing functional roles in reinforcement and memory.

The paper identifies new thermosensory and hygrosensory glomeruli and neurons in the Drosophila brain using connectomics, revealing their connections to higher brain centers and circadian clock circuits.

This study identifies molecular and neuronal changes underlying behavioural divergence in Drosophila sechellia through mutational analysis and calcium imaging.

BAcTrace is a new genetically encoded tool for retrograde neuronal tracing validated in Drosophila olfactory circuits.

The paper presents an automatic method to identify synaptic partners in a whole-brain Drosophila EM dataset using convolutional neural networks, achieving high accuracy in predicting synaptic connections.

The natverse provides an open-source R package suite for analyzing neuroanatomical data, enabling analysis, visualization, and comparison across neuronal datasets.

The paper shows that hungry Drosophila use a neural circuit involving dopamine and octopamine to balance perseverance and withdrawal during food seeking.

The paper identifies 165 cell types in the Drosophila lateral horn and shows that 33 of them have stereotyped odor responses, revealing principles of odor categorization in a higher olfactory center.

The paper identifies two LH cell-types in Drosophila that are required for aversive memory retrieval and show that memory information is passed from the mushroom body to the lateral horn.

The paper generates split-GAL4 driver lines to map and functionally characterize 82 cell types in the Drosophila lateral horn, revealing connectivity with mushroom bodies and identifying cell types that influence behavior.

The paper provides a complete electron microscopy volume of the adult Drosophila melanogaster brain, revealing new insights into synaptic connectivity and neuronal circuitry.

This paper introduces olfactogenetics to specifically activate olfactory neurons in Drosophila and identifies neuron types and brain regions involved in suppressing oviposition.

The paper introduces second-generation chemical labeling reagents for Drosophila that improve sensitivity and versatility while maintaining speed compared to first-generation tools.

NBLAST is a tool for comparing neuronal structures and clustering neurons, identifying new types and features in Drosophila datasets.

This paper introduces a chemical tagging method for rapid, low-background labeling of thick tissues, demonstrating 100x faster staining of whole-mount fly brains.