J. L. Ross Anderson

De Novo Design of Flavoproteins with Controlled Excited State Dynamics

This paper designs de novo flavoproteins with controlled excited state dynamics using computational methods and experimental validation.

Expanding all-α-helical protein space through rational computational design

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

Porphyrin driven redox tuning in structurally defined de novo heme proteins

This paper designs redox proteins with tunable electron transfer properties by replacing heme B with non-natural metalloporphyrins, achieving redox potential modulation of over 400 mV.

Delineating redox cooperativity in water-soluble and membrane multiheme cytochromes through protein design

This study uses de novo protein design to investigate redox cooperativity in multiheme cytochromes, showing that membrane burial enhances heme-heme electrostatic coupling.

Photovoltaic enzymes by design and evolution

This paper designs and evolves photoenzymes to enhance photocurrent generation for biohybrid photovoltaic devices.

Beneficial substrate partitioning boosts non-aqueous catalysis in de novo enzyme-alginate beads

This paper demonstrates that encapsulating a de novo heme-containing enzyme in calcium-alginate beads enhances its catalytic activity in non-aqueous solvents through substrate partitioning and enables enzyme recovery.

Precision design of single and multi-heme de novo proteins

The paper designs and validates de novo proteins with single and multi-heme binding capabilities, achieving atomic-level structural resolution for functional engineering.

A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase

The paper demonstrates that a de novo-designed peroxidase, C45, also functions as a promiscuous and stereoselective carbene transferase, enabling efficient ring expansion of aromatic heterocycles.