Lisa A. McIlvried

The paper identifies reciprocal plasticity and crosstalk between sympathetic and sensory nerves in oral squamous cell carcinoma, linking them to tumor progression and neuropathic-like pain.

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

The paper compares transcriptomes of native and cultured human and mouse dorsal root ganglia, finding reduced neuronal gene expression in culture but presence of key pharmacological targets.

This study identifies macrophage AT2R activation as a key driver of neuropathic pain through ROS/NO-mediated TRPA1 activation in sensory neurons.