Author

Melanie Y. Pullen

Washington University in St. LouisORCID 0000-0002-2347-3033Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:electronic health records· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Robert W. GereauiD· 2 shared Aaron D. MickleiD· 1 shared Andi WangzhouiD· 1 shared Andrew J. ShepherdiD· 1 shared Bryan A. CopitsiD· 1 shared Conrad Chris WeihliD· 1 shared Graydon B. GereauiD· 1 shared H. Henry LaiiD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Robert W. GereauORCID

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3 papers

Recent·Most cited

Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons

Lisa A. McIlvried, John Smith Del Rosario, Melanie Y. Pullen, Andi Wangzhou, Tayler D. Sheahan, Andrew J. Shepherd, Richard A. Slivicki, John A. Lemen, Theodore John Price, Bryan A. Copits, Robert W. Gereau

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

bioRxiv · Jun 13, 2023 · PreprintNeuroscience

Client processing is altered by novel myopathy-causing mutations in the HSP40 J domain

Melanie Y. Pullen, Conrad Chris Weihl, Heather L. True

The paper investigates how novel mutations in the J domain of DNAJB6 affect chaperone function in yeast, linking these changes to the pathogenesis of LGMDD1.

PLoS ONE · Jun 4, 2020Peer-reviewedMolecular Biology

Optogenetic silencing of primary afferents reduces evoked and ongoing bladder pain

Vijay K. Samineni, Aaron D. Mickle, Jangyeol Yoon, Jose G. Grajales‐Reyes, Melanie Y. Pullen, Kaitlyn E. Crawford, Kyung Nim Noh, Graydon B. Gereau, Sherri K. Vogt, H. Henry Lai, John A. Rogers, Robert W. Gereau

This study uses optogenetic inhibition of Nav1.8+ bladder sensory afferents in a mouse model of cystitis to reduce pain and hypersensitivity.

Scientific Reports · Nov 14, 2017Peer-reviewedNeuroscience