Ignacia Echeverria

The paper analyzes the structural and dynamic differences between ChikV Mac1 and SARS-CoV-2 Mac1 to explain differences in ligand binding affinity and designs inhibitors for ChikV Mac1.

EMSequenceFinder accurately assigns amino acid sequences to cryo-EM map backbone fragments, outperforming existing methods in resolution 3-10 Å maps.

This paper introduces a novel trioxane-based cross-linker, TSTO, for XL-MS that enables fast and unambiguous identification of multimeric protein interactions, revealing new structural details of protein complexes.

This study identifies the structural and sequence basis of epistatic interactions driving drug resistance in HIV by combining sequence models and molecular dynamics simulations.

This study uses structural biology to reveal the architecture of the nuclear basket in yeast and mammals, showing how Mlp/Tpr proteins form its structural components.

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.